Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.
Semin Arthritis Rheum. 2010 Oct;40(2):164-75. doi: 10.1016/j.semarthrit.2009.10.002. Epub 2009 Dec 6.
To review the literature on the role of heat-shock proteins (HSPs) in the pathogenesis of autoimmune arthritis in animal models and patients with rheumatoid arthritis (RA).
The published literature in Medline (PubMed), including our published work on the cell-mediated as well as humoral immune response to various HSPs, was reviewed. Studies in the preclinical animal models of arthritis as well as RA were examined critically and the data are presented.
In experimental arthritis, disease induction by different arthritogenic stimuli, including an adjuvant, led to immune response to mycobacterial HSP65 (BHSP65). However, attempts to induce arthritis by a purified HSP have not met with success. There are several reports of a significant immune response to HSP65 in RA patients. However, the issue of cause and effect is difficult to address. Nevertheless, several studies in animal models and a couple of clinical trials in RA patients have shown the beneficial effect of HSPs against autoimmune arthritis.
There is a clear association between immune response to HSPs, particularly HSP65, and the initiation and propagation of autoimmune arthritis in experimental models. The correlation is relatively less convincing in RA patients. In both cases, the ability of HSPs to modulate arthritis offers support, albeit an indirect one, for the involvement of these antigens in the disease process.
综述热休克蛋白（HSPs）在动物模型和类风湿关节炎（RA）患者自身免疫性关节炎发病机制中的作用的文献。
检索 Medline（PubMed）上发表的文献，包括我们关于各种 HSP 细胞介导和体液免疫反应的已发表工作。对关节炎和 RA 的临床前动物模型研究进行了批判性检查，并提供了相关数据。
在实验性关节炎中，不同关节炎诱发刺激物（包括佐剂）引起针对分枝杆菌 HSP65（BHSP65）的免疫反应。然而，用纯化 HSP 诱导关节炎的尝试并未成功。有几项报道称 RA 患者对 HSP65 有明显的免疫反应。然而，因果关系很难确定。尽管如此，一些动物模型研究和几项 RA 患者的临床试验表明 HSPs 对自身免疫性关节炎具有有益作用。
在实验模型中，HSPs（尤其是 HSP65）的免疫反应与自身免疫性关节炎的起始和传播之间存在明确的关联。在 RA 患者中，相关性的说服力相对较低。在这两种情况下，HSP 调节关节炎的能力为这些抗原参与疾病过程提供了支持，尽管是间接的支持。
