Lehigh Valley Hospital, Regional Burn Center, Allentown, PA 18103-6218, USA.
Burns. 2010 Aug;36(5):665-72. doi: 10.1016/j.burns.2009.06.193. Epub 2009 Dec 6.
This randomized, open-label study evaluated Aquacel Ag Hydrofiber dressing with silver (HDS; ConvaTec, Skillman, NJ, USA) with an adherent or gelled protocol in the management of split-thickness donor sites.
HDS was the primary dressing in the adherent group (gauze as secondary covering) and gelled group (transparent film as secondary covering). Dressings were changed on study day 1 or 2 and study days 5 (optional), 10 (optional), and 14. The primary outcome was healing (>or=90% re-epithelialization) at study day 14.
Seventy subjects were treated (36 adherent, 34 gelled). By study day 14, 77% of donor sites had healed (67% adherent, 88% gelled). Pain scores decreased over time in both treatment groups. Investigators were "very satisfied" or "satisfied" with (adherent, gelled) time required to manage dressing change (89%, 79% of subjects), minimization of donor-site pain (64%, 82%), ease of application (97%, 94%), management of drainage (92%, 82%), ease of removal (77%, 85%), and ability of dressing to remain in place (69%, 76%). Thirty-nine (56%) subjects had adverse events, most commonly non-donor-site infection (11%) and gastrointestinal events (11%).
In this randomized, open-label study, HDS was well-tolerated, versatile, and effective in the management of split-thickness donor sites.
本随机、开放性研究评估了水胶体银抗菌敷料（HDS；康维德，新泽西州斯凯勒姆，美国）在处理刃厚皮片供皮区时采用黏附或凝胶化方案的效果。
HDS 是黏附组（纱布作为二级覆盖物）和凝胶组（透明薄膜作为二级覆盖物）的主要敷料。在研究第 1 天或第 2 天和第 5 天（可选）、第 10 天（可选）和第 14 天更换敷料。主要结局指标是研究第 14 天时愈合（>90%再上皮化）。
70 例患者接受了治疗（黏附组 36 例，凝胶组 34 例）。研究第 14 天，77%的供皮区已愈合（黏附组 67%，凝胶组 88%）。两组患者的疼痛评分随时间逐渐降低。研究人员对处理敷料更换所需的时间（黏附组 89%，凝胶组 79%的患者）、最大限度减少供皮区疼痛（黏附组 64%，凝胶组 82%）、易于应用（黏附组 97%，凝胶组 94%）、引流管理（黏附组 92%，凝胶组 82%）、易于去除（黏附组 77%，凝胶组 85%）和敷料保持原位的能力（黏附组 69%，凝胶组 76%）表示“非常满意”或“满意”。39 例（56%）患者出现不良事件，最常见的是非供皮区感染（11%）和胃肠道事件（11%）。
在这项随机、开放性研究中，HDS 耐受性良好、用途广泛且在处理刃厚皮片供皮区时效果显著。
