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分层皮片供皮区创面处理的随机对照研究:比较聚氨酯敷料与藻酸钙敷料的疗效。

Split-thickness skin graft donor site management: a randomized controlled trial comparing polyurethane with calcium alginate dressings.

机构信息

Victorian Adult Burns Service, The Alfred Hospital, Commercial Road, Melbourne, Victoria, Australia.

出版信息

Int Wound J. 2012 Apr;9(2):126-31. doi: 10.1111/j.1742-481X.2011.00867.x. Epub 2011 Nov 4.

Abstract

Split-thickness skin grafting (SSG) is a common reconstructive technique for the treatment of patients with deep burns and other traumatic injuries. The management of the donor site after harvesting an SSG remains controversial because of a variety of dressings available for use. The aim of this randomized controlled trial was to compare the effectiveness of a polyurethane dressing, Allevyn™, to a calcium alginate, Kaltostat®. From August 2009 to April 2010, 36 patients were randomized to Allevyn™ or Kaltostat® for donor site management following split skin graft surgery. Pain intensity and adverse events were the primary outcomes assessed. Secondary outcome measures included time for wound healing, ease of application and removal and overall patient satisfaction. Time to first dressing change was earlier in those randomized to Allevyn™ compared with Kaltostat® (5·5 days versus 8·11 days, P = 0·014). In patients randomized to Allevyn™, excessive exudate lead to a significantly increased number of dressing changes before day 10 (14 days versus 7 days, P = 0·018). The total number of dressing changes applied was also greater in those with Allevyn™ compared with Kaltstat® (P = 0·007). There were no significant differences between the two treatment groups with respect to time to wound healing, level of pain intensity, length of stay, staff and patient satisfaction levels. This trial showed Allevyn™ to be associated with increase demands on nursing time, increased cost of dressing products, medical consumables and wastes. Kaltostat® remains the dressing of choice for initial donor site dressing in this burns unit.

摘要

分层皮片移植(SSG)是治疗深度烧伤和其他创伤患者的常用重建技术。由于有多种可供选择的敷料,因此对于 SSG 供体部位的处理仍存在争议。本随机对照试验旨在比较聚氨酯敷料 Allevyn™与藻酸钙敷料 Kaltostat®在 SSG 供体部位管理中的有效性。

2009 年 8 月至 2010 年 4 月,36 例患者随机分为 Allevyn™组或 Kaltostat®组,用于 SSG 术后供体部位管理。主要评估指标为疼痛强度和不良事件。次要评估指标包括伤口愈合时间、应用和去除的便利性以及总体患者满意度。

与 Kaltostat®组相比,随机分配到 Allevyn™组的患者首次更换敷料的时间更早(5.5 天比 8.11 天,P = 0.014)。在随机分配到 Allevyn™的患者中,过多的渗出物导致在第 10 天之前需要更换更多的敷料(14 天比 7 天,P = 0.018)。与 Kaltostat®组相比,Allevyn™组应用的敷料总数也更多(P = 0.007)。

两组在伤口愈合时间、疼痛强度水平、住院时间、工作人员和患者满意度方面无显著差异。本试验表明,Allevyn™会增加护理时间的需求,增加敷料产品、医疗耗材和废物的成本。在本烧伤单位中,Kaltostat®仍然是初始供体部位敷料的首选。

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