Nicotine Psychopharmacology Section, Intramural Research Program, National Institute on Drug Abuse, 251 Bayview Boulevard, Baltimore, MD 21224, USA.
Nicotine Tob Res. 2010 Feb;12(2):164-7. doi: 10.1093/ntr/ntp176. Epub 2009 Dec 7.
Adult and adolescent smokers regulate their nicotine and smoke intake by smoking low-yield cigarettes more intensely than high-yield cigarettes. One likely mechanism of nicotine regulation is altered puffing topography, which has been demonstrated in adult smokers. The purpose of this study was to examine the pattern of puffing behavior during the smoking of a single cigarette in adolescents.
Tobacco-dependent adolescents (n = 89) were enrolled in a treatment trial testing the efficacy of nicotine replacement therapy. About 1 week before their quit date, participants smoked ad libitum one of their usual brand of cigarettes during a laboratory session. Smoking topography measures included puff volume, puff duration, puff velocity, and interpuff interval.
Controlling for sex, race, and number of puffs, puff volume and puff duration decreased 12.8% and 24.5%, respectively, from the first 3 to the last 3 puffs. Puff velocity and interpuff interval increased 14.8% and 13.5%, respectively. Puff volume was positively correlated with puff duration and puff velocity, whereas puff duration and puff velocity were negatively correlated. However, none of the topography measures were correlated with smoking history variables.
These results suggest that adolescent smokers, like adults, are able to regulate smoke and nicotine intake on a puff-by-puff basis, therefore indicating that this aspect of smoking control is acquired early in the tobacco-dependence process.
成年和青少年吸烟者通过更强烈地吸食低产香烟来调节尼古丁和烟雾摄入量，而不是吸食高产香烟。尼古丁调节的一个可能机制是吸气流型的改变，这在成年吸烟者中已经得到证实。本研究的目的是研究青少年在吸食一支香烟时的吸气流型行为模式。
烟草依赖的青少年（n = 89）参加了一项测试尼古丁替代疗法疗效的治疗试验。在戒烟前大约一周，参与者在实验室环境中随意吸食他们通常品牌的香烟。吸烟地形测量包括吸气流速、吸气流速、吸气流速和吸气流速。
控制性别、种族和吸烟量，与前 3 口相比，最后 3 口的吸气流速和吸气流速分别下降 12.8%和 24.5%。吸气流速和吸气流速分别增加 14.8%和 13.5%。吸气流速与吸气流速和吸气流速呈正相关，而吸气流速和吸气流速呈负相关。然而，吸气流速的任何指标都与吸烟史变量无关。
这些结果表明，青少年吸烟者和成年人一样，能够在每一口的基础上调节烟雾和尼古丁的摄入，这表明吸烟控制的这一方面是在烟草依赖过程的早期获得的。
