Tampere School of Public Health, University of Tampere, Finland.
Pediatrics. 2010 Jan;125(1):50-9. doi: 10.1542/peds.2009-0813. Epub 2009 Dec 7.
The goal was to examine the relationship between age at the introduction of solid foods during the first year of life and allergic sensitization in 5-year-old children.
We analyzed data from the Finnish Type 1 Diabetes Prediction and Prevention nutrition study, a prospective, birth cohort study. We studied 994 children with HLA-conferred susceptibility to type 1 diabetes mellitus for whom information on breastfeeding, age at the introduction of solid foods, and allergen-specific immunoglobulin E levels at 5 years was available. The association between age at the introduction of solid foods and allergic sensitization was analyzed by using logistic regression.
The median duration of exclusive breastfeeding was 1.8 months (range: 0-10 months). After adjustment for potential confounders, late introduction of potatoes (>4 months), oats (>5 months), rye (>7 months), wheat (>6 months), meat (>5.5 months), fish (>8.2 months), and eggs (>10.5 months) was significantly directly associated with sensitization to food allergens. Late introduction of potatoes, rye, meat, and fish was significantly associated with sensitization to any inhalant allergen. In models that included all solid foods that were significantly related to the end points, eggs, oats, and wheat remained the most important foods related to sensitization to food allergens, whereas potatoes and fish were the most important foods associated with inhalant allergic sensitization. We found no evidence of reverse causality, taking into account parental allergic rhinitis and asthma.
Late introduction of solid foods was associated with increased risk of allergic sensitization to food and inhalant allergens.
研究婴儿期第一年固体食物引入的年龄与 5 岁儿童过敏致敏之间的关系。
我们分析了芬兰 1 型糖尿病预测和预防营养研究的数据，这是一项前瞻性出生队列研究。我们研究了 994 名具有 1 型糖尿病 HLA 易感性的儿童，这些儿童的信息包括母乳喂养、固体食物引入年龄和 5 岁时的过敏原特异性免疫球蛋白 E 水平。使用逻辑回归分析固体食物引入年龄与过敏致敏之间的关联。
纯母乳喂养的中位数持续时间为 1.8 个月（范围：0-10 个月）。在调整潜在混杂因素后，土豆（>4 个月）、燕麦（>5 个月）、黑麦（>7 个月）、小麦（>6 个月）、肉（>5.5 个月）、鱼（>8.2 个月）和鸡蛋（>10.5 个月）的延迟引入与食物过敏原致敏显著正相关。土豆、黑麦、肉和鱼的延迟引入与任何吸入性过敏原致敏显著相关。在包括与终点显著相关的所有固体食物的模型中，鸡蛋、燕麦和小麦仍然是与食物过敏原致敏最相关的最重要食物，而土豆和鱼是与吸入性过敏致敏最相关的最重要食物。考虑到父母的过敏性鼻炎和哮喘，我们没有发现反向因果关系的证据。
固体食物引入较晚与食物和吸入性过敏原致敏的风险增加有关。
