结直肠癌患者的白细胞碱性磷酸酶和癌胚抗原（在分期评估中的应用价值）

Leukocyte alkaline phosphatase and carcinoembryonic antigen in colorectal cancer patients (usefulness in the assessment of the stage).

作者信息

Walach N, Guterman A, Zaidman J L, Kaufman S, Scharf S

机构信息

Department of Oncology, Assaf Harofeh Medical Center, Zerifin, Israel.

出版信息

Oncology. 1991;48(2):128-30. doi: 10.1159/000226911.

DOI:10.1159/000226911

PMID:1997936

Abstract

Leukocyte alkaline phosphatase (LAP) scores in peripheral blood, and plasma carcinoembryonic antigen (CEA) levels were determined in 122 colorectal cancer patients, and compared to 30 healthy persons, who served as controls. Both markers are gradually elevated according to the severity of tumor penetration. LAP scores in Dukes'C and D (157 +/- 79) were significantly higher than in Dukes'A, B1 and B2 (81 +/- 43), p less than 0.001. CEA levels were also higher in Dukes'C and D (50 +/- 95) than in patients with Dukes'A, B1 and B2 (25 +/- 54), p less than 0.07, but less significantly. The LAP score has at least the same reliability as the CEA values as a marker of stage in colorectal cancer patients.

摘要

对122例结直肠癌患者测定了外周血白细胞碱性磷酸酶（LAP）评分及血浆癌胚抗原（CEA）水平，并与30名健康人进行比较，后者作为对照。这两种标志物均随肿瘤浸润严重程度而逐渐升高。Dukes'C期和D期患者的LAP评分（157±79）显著高于Dukes'A期、B1期和B2期患者（81±43），p<0.001。Dukes'C期和D期患者的CEA水平（50±95）也高于Dukes'A期、B1期和B2期患者（25±54），p<0.07，但差异不太显著。作为结直肠癌患者分期的标志物，LAP评分至少与CEA值具有相同的可靠性。