Yonemura Y, Kimura H, Ooyama S, Kamata T, Yamaguchi A, Matsumoto H, Ninomiya I, Miyazaki I
Surgery II. School of Medicine, Kanazawa University, Japan.
Oncology. 1991;48(2):162-5. doi: 10.1159/000226918.
The growth fractions in endoscopically biopsied materials from 121 patients with gastric carcinomas were determined by immunohistochemical staining with the monoclonal antibody Ki-67 and the results correlated with the histopathologic findings and clinical outcome. The Ki-67 labeling rates ranged from 4.6 to 52% (mean: 22%). A significant correlation was found between Ki-67 labeling rates of biopsied materials and those of resected specimens. The tumors showing Ki-67 labeling rates of greater than 22% are more likely to have lymph node metastasis, lymphatic invasion of serosal invasion than those with the rates below 22%. In addition, Ki-67 labeling rates were closely associated with prognosis. Tumors with high Ki-67 labeling rates (greater than 22%) were related to poor prognosis, whereas those with low Ki-67 labeling rates were associated with favorable prognosis. The immunohistochemical staining of proliferating cells in endoscopically biopsied specimens of gastric carcinomas using the Ki-67 monoclonal antibody may be useful in assessing prognosis in carcinoma of the stomach.
采用单克隆抗体Ki-67免疫组化染色法测定了121例胃癌患者内镜活检材料中的增殖分数，并将结果与组织病理学发现及临床转归进行了关联分析。Ki-67标记率在4.6%至52%之间（平均为22%）。活检材料与切除标本的Ki-67标记率之间存在显著相关性。Ki-67标记率大于22%的肿瘤比标记率低于22%的肿瘤更易发生淋巴结转移、淋巴管侵犯或浆膜侵犯。此外，Ki-67标记率与预后密切相关。Ki-67标记率高（大于22%）的肿瘤预后较差，而标记率低的肿瘤预后良好。使用Ki-67单克隆抗体对胃癌内镜活检标本中的增殖细胞进行免疫组化染色，可能有助于评估胃癌的预后。
