Fatma N, Jain A K, Rahman Q
ICMR Centre for Advanced Research in Genetics, Department of Medicine, KG's Medical College, Lucknow, India.
Br J Ind Med. 1991 Feb;48(2):103-5. doi: 10.1136/oem.48.2.103.
Exposure to asbestos minerals has been associated with a wide variety of adverse health effects including lung cancer, pleural mesothelioma, and cancer of other organs. It was shown previously that asbestos samples collected from a local asbestos factory enhanced sister chromatid exchanges (SCEs) and chromosomal aberrations in vitro using human lymphocytes. In the present study, 22 workers from the same factory and 12 controls were further investigated. Controls were matched for age, sex, and socioeconomic state. The peripheral blood lymphocytes were cultured and harvested at 48 hours for studies of chromosomal aberrations and at 72 hours for SCE frequency determinations. Asbestos workers had a raised mean SCE rate and increased numbers of chromosomal aberrations compared with a control population. Most of the chromosomal aberrations were chromatid gap and break types.
接触石棉矿物与多种不良健康影响有关，包括肺癌、胸膜间皮瘤和其他器官的癌症。先前的研究表明，从当地一家石棉厂采集的石棉样本在体外使用人淋巴细胞可增强姐妹染色单体交换（SCE）和染色体畸变。在本研究中，对同一家工厂的22名工人和12名对照进行了进一步调查。对照在年龄、性别和社会经济状况方面进行了匹配。外周血淋巴细胞在48小时培养后收获用于染色体畸变研究，在72小时培养后收获用于SCE频率测定。与对照人群相比，石棉工人的平均SCE率升高，染色体畸变数量增加。大多数染色体畸变是染色单体间隙和断裂类型。
