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阻塞性睡眠呼吸暂停与中风

Obstructive sleep apnea and stroke.

作者信息

Dyken Mark Eric, Im Kyoung Bin

机构信息

Sleep Disorders Center, the Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA.

Sleep Disorders Center, the Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA.

出版信息

Chest. 2009 Dec;136(6):1668-1677. doi: 10.1378/chest.08-1512.

Abstract

Obstructive sleep apnea (OSA) and stroke are frequent, multifactorial entities that share risk factors, and for which case-control and cross-sectional studies have shown a strong association. Stroke of respiratory centers can lead to apnea. Snoring preceding stroke, documentation of apneas immediately prior to transient ischemic attacks, the results of autonomic studies, and the circadian pattern of stroke, suggest that untreated OSA can contribute to stroke. Although cohort studies indicate that OSA is a stroke risk factor, controversy surrounds the cost-effectiveness of the screening for and treatment of OSA once stroke has occurred.

摘要

阻塞性睡眠呼吸暂停(OSA)和中风是常见的、多因素的病症,它们有共同的危险因素,病例对照研究和横断面研究已表明二者之间存在密切关联。呼吸中枢中风可导致呼吸暂停。中风前的打鼾、短暂性脑缺血发作前即刻的呼吸暂停记录、自主神经研究结果以及中风的昼夜模式,均提示未经治疗的OSA可能导致中风。尽管队列研究表明OSA是中风的一个危险因素,但对于中风发生后筛查和治疗OSA的成本效益仍存在争议。

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