Department of Chemistry and Biochemistry, The University of Arizona, Tucson, Arizona 85721, USA.
J Org Chem. 2009 Dec 18;74(24):9245-64. doi: 10.1021/jo901767e.
From a scientific perspective, efforts to understand biology including what constitutes health and disease has become a chemical problem. However, chemists and biologists "see" the problems of understanding biology from different perspectives, and this has retarded progress in solving the problems especially as they relate to health and disease. This suggests that close collaboration between chemists and biologists is not only necessary but essential for progress in both the biology and chemistry that will provide solutions to the global questions of biology. This perspective has directed my scientific efforts for the past 45 years, and in this overview I provide my perspective of how the applications of synthetic chemistry, structural design, and numerous other chemical principles have intersected in my collaborations with biologists to provide new tools, new science, and new insights that were only made possible and fruitful by these collaborations.
从科学的角度来看，理解生物学（包括健康和疾病的构成）的努力已经成为一个化学问题。然而，化学家与生物学家从不同的视角“看待”生物学问题，这阻碍了问题的解决进展，尤其是在与健康和疾病相关的问题方面。这表明，化学家与生物学家之间的密切合作不仅是必要的，而且对于生物学和化学的进展也是至关重要的，因为这将为生物学的全球性问题提供解决方案。这一观点指导了我过去 45 年的科学努力，在这篇综述中，我提供了自己的观点，即合成化学的应用、结构设计以及许多其他化学原理是如何在与生物学家的合作中交汇的，这些合作提供了新的工具、新的科学和新的见解，这些合作使这些新的工具、科学和见解成为可能并富有成效。
