对细菌感染的抵抗力：种间差异可能归因于血清中的蛋白质。
Resilience to bacterial infection: difference between species could be due to proteins in serum.
机构信息
Infectious Disease Unit, Institut Pasteur, Paris, France.
出版信息
J Infect Dis. 2010 Jan 15;201(2):223-32. doi: 10.1086/649557.
Abstract
Vertebrates vary in resistance and resilience to infectious diseases, and the mechanisms that regulate the trade-off between these often opposing protective processes are not well understood. Variability in the sensitivity of species to the induction of damaging inflammation in response to equivalent pathogen loads (resilience) complicates the use of animal models that reflect human disease. We found that induction of proinflammatory cytokines from macrophages in response to inflammatory stimuli in vitro is regulated by proteins in the sera of species in inverse proportion to their in vivo resilience to lethal doses of bacterial lipopolysaccharide over a range of 10,000-fold. This finding suggests that proteins in serum rather than intrinsic cellular differences may play a role in regulating variations in resilience to microbe-associated molecular patterns between species. The involvement of circulating proteins as key molecules raises hope that the process might be manipulated to create better animal models and potentially new drug targets.
摘要
脊椎动物对传染病的抵抗力和恢复力各不相同，而调节这两种经常相互矛盾的保护过程之间权衡的机制还不太清楚。物种对等效病原体负荷引起的破坏性炎症的敏感性的变异性（恢复力）使得反映人类疾病的动物模型的使用变得复杂。我们发现，体外炎症刺激下巨噬细胞产生促炎细胞因子的反应受血清中蛋白质的调节，而这些蛋白质的血清浓度与物种对致死剂量细菌脂多糖的体内恢复力呈反比，范围为 10000 倍。这一发现表明，血清中的蛋白质而不是细胞内在的差异可能在调节物种间与微生物相关的分子模式的恢复力差异方面发挥作用。循环蛋白作为关键分子的参与带来了希望，即该过程可能被操纵以创建更好的动物模型，并可能成为新的药物靶点。
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