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体外研究新生儿呼吸窘迫综合征时气管神经节的体积密度。

The study of volume density of tracheal ganglions in vitro in new born babies with respiratory distress syndrome.

机构信息

Department of Pathology, Faculty of Medicine, University of Prishtina, Clinics Centre N.N. 10000, Prishtina, Kosovo.

出版信息

Bosn J Basic Med Sci. 2009 Nov;9(4):335-41. doi: 10.17305/bjbms.2009.2790.

Abstract

Volume density of respiratory organs was studied in vitro in newborn babies at different age of gestation (abort, immature, premature and mature) using stereometric method. The total of 23 cases was subject to this study. The respiratory organs (trachea, lungs) were taken from autopsies of newborn babies exited from different causes. For this purpose the tissues were fixed in formalin (10%) solution, cut serially in 7micro and 10micro slabs. Volume density of the respiratory system was assessed stereometricaly using Universal testing system Weibel M 42. We observed that volume density of epithelia, musculature and glands were proportionally present in the tracheal tissue. Cellular interstitial tissue is consistently increasing and corresponds to the developmental stages of the newborn babies. The density of tracheal ganglions is greater in premature ages of immature and premature newborns (p<0,05). Decreased number of ganglion cells is observed in mature ages (p<0,05). This is caused by intensive ramification of ganglions from serosa to deeper layers of trachea right to epithelium. Medium diameter of tracheal ganglions is greater in mature newborn babies and corresponds to developmental ages of babies.

摘要

采用体视学法研究了不同胎龄(流产、未成熟、早产和成熟)新生儿呼吸器官的体积密度。共有 23 例参与了这项研究。呼吸器官(气管、肺)取自因不同原因死亡的新生儿的尸检。为此,组织在福尔马林(10%)溶液中固定,以 7μm 和 10μm 切片连续切片。使用通用测试系统 Weibel M 42 体视学法评估呼吸系统的体积密度。我们观察到,上皮、肌肉和腺体的体积密度在气管组织中呈比例存在。细胞间组织不断增加,与新生儿的发育阶段相对应。在未成熟和早产的早产儿中,气管神经节的密度在早产阶段较大(p<0.05)。在成熟阶段观察到神经节细胞数量减少(p<0.05)。这是由于神经节从浆膜到气管深层的上皮的密集分支引起的。成熟新生儿的气管神经节的中径较大,与婴儿的发育年龄相对应。

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