VU University Medical Centre, Amsterdam and Amphia Hospital, Breda, The Netherlands.
Clin Microbiol Infect. 2010 Jan;16(1):11-5. doi: 10.1111/j.1469-0691.2009.03110.x.
The widespread use of antimicrobial agents, in combination with insufficient infection control measures, is the main driver of the current pandemic of antimicrobial resistance in human pathogens. The use of antimicrobials in food animal production also contributes, because resistant organisms and resistance genes can spread from animals to humans by direct contact or through the food chain. An important, traditionally human, pathogen, methicillin-resistant Staphylococcus aureus (MRSA), is currently endemic in many hospitals around the world and has also emerged in the community. Recently, a new reservoir of MRSA has been identified in food production animals and people in contact with these animals. This involves a specific clone, multilocus sequence type 398 (ST398), which has spread extensively among animals. ST398 has also been found in up to 11.9% of retail meat samples in several surveys from different parts of the world, posing a potential threat to human health.
抗菌药物的广泛使用，加上感染控制措施不足，是当前人类病原体对抗菌药物耐药性流行的主要驱动因素。在食品动物生产中使用抗菌药物也起到了一定作用，因为耐药菌和耐药基因可以通过直接接触或食物链从动物传播给人类。耐甲氧西林金黄色葡萄球菌（MRSA）是一种重要的、传统上存在于人类中的病原体，目前在世界许多医院中流行，并已在社区中出现。最近，在与这些动物接触的食品生产动物和人群中发现了一个新的 MRSA 储库。这涉及到一个特定的克隆，多基因序列型 398（ST398），它在动物中广泛传播。在来自世界不同地区的几项调查中，ST398 也在高达 11.9%的零售肉样本中被发现，对人类健康构成潜在威胁。
