European Concerted Action on New Generation Genetic Markers and Techniques for the Epidemiology and Control of Tuberculosis RIVM, Bilthoven, the Netherlands.
Emerg Infect Dis. 2006 May;12(5):736-43. doi: 10.3201/eid1205.050400.
Beijing/W genotype Mycobacterium tuberculosis is widespread, may be increasing, and may have a predilection for drug resistance. Individual-level data on >29,000 patients from 49 studies in 35 countries were combined to assess the Beijing genotype's prevalence worldwide, trends over time and with age, and associations with drug resistance. We found 4 patterns for Beijing/W genotype tuberculosis (TB): 1) endemic, not associated with drug resistance (high level in most of East Asia, lower level in parts of the United States); 2) epidemic, associated with drug resistance (high level in Cuba, the former Soviet Union, Vietnam, and South Africa, lower level in parts of Western Europe); 3) epidemic but drug sensitive (Malawi, Argentina); and 4) very low level or absent (parts of Europe, Africa). This study confirms that Beijing/W genotype TB is an emerging pathogen in several areas and a predominant endemic strain in others; it is frequently associated with drug resistance.
北京/W基因型结核分枝杆菌广泛存在，可能呈上升趋势，并且可能易产生耐药性。对来自35个国家49项研究的29000多名患者的个体水平数据进行合并分析，以评估北京基因型在全球的流行情况、随时间和年龄的变化趋势以及与耐药性的关联。我们发现北京/W基因型结核病（TB）有4种模式：1）地方性流行，与耐药性无关（在东亚大部分地区水平较高，在美国部分地区水平较低）；2）流行性，与耐药性有关（在古巴、前苏联、越南和南非水平较高，在西欧部分地区水平较低）；3）流行性但对药物敏感（马拉维、阿根廷）；4）极低水平或不存在（欧洲部分地区、非洲部分地区）。这项研究证实，北京/W基因型结核病在一些地区是新兴病原体，在其他地区是主要的地方性菌株；它经常与耐药性相关。
