Exp Neurol. 2010 May;223(1):1-4. doi: 10.1016/j.expneurol.2009.12.001. Epub 2009 Dec 18.
Regeneration in the peripheral nervous system offers unique opportunities and challenges to medicine. Compared to the central nervous system, peripheral axons can and do regenerate resulting in functional recovery, especially if the distance to target is short as in distal limb injuries. However, this regenerative capacity is often incomplete and functional recovery with proximal lesions is limited. Furthermore, regeneration of axons to the appropriate targets remains a challenge with inappropriate reinnervation being an impediment to full recovery. The reviews and selected original research papers in this Special Issue will address some of these challenges and highlight new opportunities for development of effective therapies for nerve regeneration.
外周神经系统的再生为医学提供了独特的机会和挑战。与中枢神经系统相比,外周轴突可以再生,并且确实可以再生,从而导致功能恢复,尤其是在距离靶标较近的情况下,如远端肢体损伤。但是,这种再生能力通常是不完全的,近端病变的功能恢复是有限的。此外,轴突向适当靶标的再生仍然是一个挑战,而不适当的神经再支配是完全恢复的障碍。本期特刊中的评论和精选原始研究论文将解决其中的一些挑战,并为开发有效的神经再生治疗方法提供新的机会。