特刊介绍：周围神经系统再生的挑战与机遇。
Introduction to special issue: Challenges and opportunities for regeneration in the peripheral nervous system.
出版信息
Exp Neurol. 2010 May;223(1):1-4. doi: 10.1016/j.expneurol.2009.12.001. Epub 2009 Dec 18.
Abstract
Regeneration in the peripheral nervous system offers unique opportunities and challenges to medicine. Compared to the central nervous system, peripheral axons can and do regenerate resulting in functional recovery, especially if the distance to target is short as in distal limb injuries. However, this regenerative capacity is often incomplete and functional recovery with proximal lesions is limited. Furthermore, regeneration of axons to the appropriate targets remains a challenge with inappropriate reinnervation being an impediment to full recovery. The reviews and selected original research papers in this Special Issue will address some of these challenges and highlight new opportunities for development of effective therapies for nerve regeneration.
摘要
外周神经系统的再生为医学提供了独特的机会和挑战。与中枢神经系统相比，外周轴突可以再生，并且确实可以再生，从而导致功能恢复，尤其是在距离靶标较近的情况下，如远端肢体损伤。但是，这种再生能力通常是不完全的，近端病变的功能恢复是有限的。此外，轴突向适当靶标的再生仍然是一个挑战，而不适当的神经再支配是完全恢复的障碍。本期特刊中的评论和精选原始研究论文将解决其中的一些挑战，并为开发有效的神经再生治疗方法提供新的机会。
相似文献
1
Introduction to special issue: Challenges and opportunities for regeneration in the peripheral nervous system.特刊介绍：周围神经系统再生的挑战与机遇。
Exp Neurol. 2010 May;223(1):1-4. doi: 10.1016/j.expneurol.2009.12.001. Epub 2009 Dec 18.
2
Analysis of axonal regeneration in the central and peripheral nervous systems of the NG2-deficient mouse.NG2基因缺陷小鼠中枢和外周神经系统中轴突再生的分析。
BMC Neurosci. 2007 Sep 27;8:80. doi: 10.1186/1471-2202-8-80.
3
Electrical stimulation for promoting peripheral nerve regeneration.电刺激促进周围神经再生。
Int Rev Neurobiol. 2013;109:111-24. doi: 10.1016/B978-0-12-420045-6.00005-5.
4
Motor axon regeneration and muscle reinnervation in young adult and aged animals.年轻成年和老年动物的运动轴突再生和肌肉神经再支配。
J Neurosci. 2013 Dec 11;33(50):19480-91. doi: 10.1523/JNEUROSCI.4067-13.2013.
5
Axon regeneration in the peripheral and central nervous systems.外周和中枢神经系统中的轴突再生。
Results Probl Cell Differ. 2009;48:339-51. doi: 10.1007/400_2009_19.
6
The specificity of motor neurone regeneration (preferential reinnervation).运动神经元再生的特异性（优先再支配）。
Acta Physiol (Oxf). 2007 Feb;189(2):201-6. doi: 10.1111/j.1748-1716.2006.01657.x.
8
Intrinsic Determinants of Axon Regeneration.轴突再生的内在决定因素。
Dev Neurobiol. 2018 Oct;78(10):890-897. doi: 10.1002/dneu.22637. Epub 2018 Oct 21.
9
Imaging axon regeneration within synthetic nerve conduits.在合成神经导管内成像轴突再生。
Sci Rep. 2019 Jul 12;9(1):10095. doi: 10.1038/s41598-019-46579-w.
10
Upslope treadmill exercise enhances motor axon regeneration but not functional recovery following peripheral nerve injury.上坡跑步机运动可促进周围神经损伤后运动轴突的再生，但不能促进功能恢复。
J Neurophysiol. 2016 Sep 1;116(3):1408-17. doi: 10.1152/jn.00129.2016. Epub 2016 Jul 27.
引用本文的文献
1
Application of Mesenchymal Stem Cell-Derived Schwann Cell-like Cells Spared Neuromuscular Junctions and Enhanced Functional Recovery After Peripheral Nerve Injury.间充质干细胞来源的雪旺细胞样细胞在外周神经损伤后对神经肌肉接头的保留及功能恢复的促进作用
Cells. 2024 Dec 23;13(24):2137. doi: 10.3390/cells13242137.
2
Target specification and therapeutic potential of extracellular vesicles for regulating corneal angiogenesis, lymphangiogenesis, and nerve repair.用于调节角膜血管生成、淋巴管生成和神经修复的细胞外囊泡的靶点特性及治疗潜力
Ocul Surf. 2024 Oct;34:459-476. doi: 10.1016/j.jtos.2024.10.005. Epub 2024 Oct 18.
3
Efficacy of using adipose-derived stem cells and PRP on regeneration of 40 -mm long sciatic nerve defect bridged by polyglycolic-polypropylene mesh in canine model.脂肪源性干细胞和 PRP 促进聚乙二醇-聚对苯二甲酸丙二醇酯网修复犬 40mm 长坐骨神经缺损的效果。
Stem Cell Res Ther. 2024 Jul 18;15(1):212. doi: 10.1186/s13287-024-03796-z.
4
Early Intensive Neurorehabilitation in Traumatic Peripheral Nerve Injury-State of the Art.创伤性周围神经损伤的早期强化神经康复——最新进展
Animals (Basel). 2024 Mar 13;14(6):884. doi: 10.3390/ani14060884.
5
Application of Electrical Stimulation to Enhance Axon Regeneration Following Peripheral Nerve Injury.应用电刺激促进周围神经损伤后的轴突再生。
Bio Protoc. 2023 Oct 5;13(19):e4833. doi: 10.21769/BioProtoc.4833.
6
Therapeutic Potential of "Smart" Exosomes in Peripheral Nerve Regeneration.“智能”外泌体在周围神经再生中的治疗潜力
J Biotechnol Biomed. 2023;6(2):189-196. doi: 10.26502/jbb.2642-91280082. Epub 2023 May 4.
7
Nerve trunk healing and neuroma formation after nerve transection injury.神经横断损伤后的神经干愈合与神经瘤形成。
Front Neurol. 2023 Jun 12;14:1184246. doi: 10.3389/fneur.2023.1184246. eCollection 2023.
8
Collagen for neural tissue engineering: Materials, strategies, and challenges.用于神经组织工程的胶原蛋白：材料、策略与挑战
Mater Today Bio. 2023 May 2;20:100639. doi: 10.1016/j.mtbio.2023.100639. eCollection 2023 Jun.
9
Effect of combined intervention of exercise and autologous bone marrow stromal cell transplantation on neurotrophic factors and pain-related cascades over time after sciatic nerve injury.运动与自体骨髓基质细胞移植联合干预对坐骨神经损伤后不同时间神经营养因子及疼痛相关级联反应的影响
J Exerc Rehabil. 2023 Feb 23;19(1):19-26. doi: 10.12965/jer.2244006.003. eCollection 2023 Feb.
10
Exploring the Nerve Regenerative Capacity of Compounds with Differing Affinity for PPARγ In Vitro and In Vivo.探讨具有不同 PPARγ 亲和力的化合物在体外和体内的神经再生能力。
Cells. 2022 Dec 22;12(1):42. doi: 10.3390/cells12010042.
本文引用的文献
1
Preferential motor reinnervation: a sequential double-labeling study.优先运动神经再支配：一项序贯双重标记研究。
Restor Neurol Neurosci. 1990 Jan 1;1(3):281-7. doi: 10.3233/RNN-1990-13416.
2
Guiding adult Mammalian sensory axons during regeneration.引导成年哺乳动物感觉轴突再生。
J Neuropathol Exp Neurol. 2008 Mar;67(3):212-22. doi: 10.1097/NEN.0b013e3181654972.
3
ATF3 increases the intrinsic growth state of DRG neurons to enhance peripheral nerve regeneration.活化转录因子3（ATF3）增强背根神经节神经元的内在生长状态以促进周围神经再生。
J Neurosci. 2007 Jul 25;27(30):7911-20. doi: 10.1523/JNEUROSCI.5313-06.2007.
4
On the suture of separate nerve bundles in a nerve trunk and on internal nerve plexuses.关于神经干中分离神经束的缝合及内部神经丛的研究
J Physiol. 1917 Sep 12;51(4-5):318-46. doi: 10.1113/jphysiol.1917.sp001805.
5
Schwann cells express motor and sensory phenotypes that regulate axon regeneration.施万细胞表达调节轴突再生的运动和感觉表型。
J Neurosci. 2006 Sep 20;26(38):9646-55. doi: 10.1523/JNEUROSCI.1620-06.2006.
6
Mechanisms of Disease: what factors limit the success of peripheral nerve regeneration in humans?疾病机制：哪些因素限制了人类周围神经再生的成功？
Nat Clin Pract Neurol. 2006 Aug;2(8):448-54. doi: 10.1038/ncpneuro0262.
7
The transcription factor ATF-3 promotes neurite outgrowth.转录因子ATF-3促进神经突生长。
Mol Cell Neurosci. 2006 May-Jun;32(1-2):143-54. doi: 10.1016/j.mcn.2006.03.005. Epub 2006 May 19.
8
Proteoglycans in axonal regeneration.轴突再生中的蛋白聚糖
Exp Neurol. 2005 Oct;195(2):273-7. doi: 10.1016/j.expneurol.2005.06.016.
9
Axon regeneration in peripheral nerves is enhanced by proteoglycan degradation.蛋白聚糖降解可增强周围神经中的轴突再生。
Exp Neurol. 2005 Oct;195(2):278-92. doi: 10.1016/j.expneurol.2005.04.007.
10
Pathway sampling by regenerating peripheral axons.通过再生外周轴突进行通路采样。
J Comp Neurol. 2005 May 9;485(3):183-90. doi: 10.1002/cne.20436.
Zotero 插件