磺酰基和膦酰基脒类化合物的合成及构效关系研究作为抗吸收剂。
Synthesis and SAR of sulfonyl- and phosphoryl amidine compounds as anti-resorptive agents.
机构信息
Department of Chemistry and Medical Chemistry, Yonsei University, Wonju 220-710, Republic of Korea.
出版信息
Bioorg Med Chem Lett. 2010 Jan 15;20(2):541-5. doi: 10.1016/j.bmcl.2009.11.104. Epub 2009 Nov 26.
PMID:20005100
Abstract
Sulfonyl amidines (1) and phosphoryl amidines (2), which were efficiently synthesized via a Cu-catalyzed one pot reaction, showed potent anti-bone resorptive activity in vitro. Structure activity relationship studies led to the identification of numerous osteoclast differentiation inhibitors.
摘要
磺酰基脒（1）和磷酰基脒（2）可通过 Cu 催化的一锅法反应高效合成，在体外显示出很强的抗骨吸收活性。构效关系研究鉴定了许多破骨细胞分化抑制剂。
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