EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands.
Metabolism. 2010 Jun;59(6):854-60. doi: 10.1016/j.metabol.2009.10.002. Epub 2009 Dec 16.
The aim of the study was to test whether fasting or postprandial cholesteryl ester transfer protein (CETP) concentrations are associated with postprandial changes in high-density lipoprotein cholesterol (HDL-c) concentrations after fat-rich or carbohydrate-rich meals. Postmenopausal women (76 with normal glucose metabolism [NGM], 41 with type 2 diabetes mellitus [T2DM], and 38 T2DM women with statin therapy [T2DM-ST]) received 2 consecutive fat-rich or carbohydrate-rich meals on separate occasions. Linear regression analysis was performed to assess the associations of fasting CETP and postprandial changes of CETP with postprandial changes in HDL-c. Mean plasma HDL-c concentrations decreased significantly after the fat-rich meals: 0.18 +/- 0.09 mmol/L in NGM, 0.16 +/- 0.09 mmol/L in T2DM, and 0.14 +/- 0.08 mmol/L in T2DM-ST women. This effect was smaller after using carbohydrate-rich meals: 0.12 +/- 0.09 mmol/L in the NGM, 0.12 +/- 0.08 mmol/L in the T2DM, and 0.10 +/- 0.05 mmol/L in the T2DM-ST study group. Higher fasting but not postprandial CETP concentrations were associated with a larger postprandial decrease in HDL-c (beta -0.034; 95% confidence interval, -0.067 to -0.001) after the fat-rich meals. This association was independent of the postprandial increase in triglycerides and similar among the 3 study groups. A high fasting CETP concentration may contribute to the postprandial atherogenic lipoprotein profile in postmenopausal women by decreasing HDL-c after fat-rich meals. This effect is independent from the postprandial increase in triglycerides.
本研究旨在测试空腹或餐后胆甾醇酯转移蛋白（CETP）浓度是否与富含脂肪或富含碳水化合物的餐后高密度脂蛋白胆固醇（HDL-c）浓度的餐后变化相关。将绝经后妇女（76 名葡萄糖代谢正常 [NGM]，41 名 2 型糖尿病 [T2DM]，38 名 T2DM 合并他汀治疗 [T2DM-ST]）分两次分别摄入富含脂肪或富含碳水化合物的餐食。采用线性回归分析评估空腹 CETP 与 CETP 的餐后变化与 HDL-c 的餐后变化之间的相关性。结果显示，摄入富含脂肪的餐后，HDL-c 平均血浆浓度显著下降：NGM 组为 0.18 ± 0.09 mmol/L，T2DM 组为 0.16 ± 0.09 mmol/L，T2DM-ST 组为 0.14 ± 0.08 mmol/L。摄入富含碳水化合物的餐后，这一作用较小：NGM 组为 0.12 ± 0.09 mmol/L，T2DM 组为 0.12 ± 0.08 mmol/L，T2DM-ST 组为 0.10 ± 0.05 mmol/L。较高的空腹但不是餐后 CETP 浓度与富含脂肪的餐后 HDL-c 餐后降低幅度较大相关（β-0.034；95%置信区间，-0.067 至 -0.001）。这种相关性独立于餐后甘油三酯的增加，并且在 3 个研究组中相似。高空腹 CETP 浓度可能通过在富含脂肪的餐后降低 HDL-c 来促进绝经后妇女的餐后致动脉粥样硬化脂蛋白谱。这种作用独立于餐后甘油三酯的增加。
