Department of Pediatrics, Haseki Education and Research Hospital, Istanbul, Turkey.
Int J Infect Dis. 2010 Sep;14 Suppl 3:e213-6. doi: 10.1016/j.ijid.2009.07.017. Epub 2009 Dec 14.
Crimean-Congo hemorrhagic fever (CCHF) is a fatal viral disease that occurs in approximately 30 countries. It has the most extensive geographic range among the tick-borne viruses that affect human health. Recently, a 6-year-old boy presented with complaints of fever, fatigue, and loss of appetite. He revealed a history of tick bite in rural Istanbul three days prior to presentation. A hyperemia was detected at the site of the tick bite. Laboratory tests showed that alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, and creatine phosphokinase levels were elevated and that the prothrombin time and activated partial thromboplastin time were prolonged. Anti-CCHF virus IgM ELISA and a reverse transcriptase-PCR assay for CCHF RNA were both positive. Phylogenetic studies revealed that the virus was a new AP92-like CCHF strain, which was named KMAG-Hu-07-01 (accession number EU057975). This patient could provide important information on the transmission dynamics of CCHF infection.
克里米亚-刚果出血热（CCHF）是一种致命的病毒性疾病，发生在大约 30 个国家。它在影响人类健康的蜱传病毒中具有最广泛的地理范围。最近，一名 6 岁男孩出现发热、疲劳和食欲不振等症状。他透露，在出现症状前三天，曾在伊斯坦布尔农村被蜱虫叮咬。在蜱虫叮咬部位发现充血。实验室检查显示丙氨酸氨基转移酶、天冬氨酸氨基转移酶、乳酸脱氢酶和肌酸磷酸激酶水平升高，凝血酶原时间和部分活化凝血活酶时间延长。抗 CCHF 病毒 IgM ELISA 和 CCHF RNA 的逆转录-PCR 检测均为阳性。系统进化研究表明，该病毒是一种新的 AP92 样 CCHF 株，被命名为 KMAG-Hu-07-01（登录号：EU057975）。该患者可以为 CCHF 感染的传播动态提供重要信息。
