Robert Koch Institute, Wernigerode Branch, Burgstrasse 37, 38855 Wernigerode, Germany.
Int J Med Microbiol. 2010 Feb;300(2-3):109-17. doi: 10.1016/j.ijmm.2009.11.002. Epub 2009 Dec 16.
The emergence of methicillin-resistant Staphylococcus aureus (MRSA) in animals such as horses, pet animals and productive livestock has raised questions of a probable human origin and in more general of host specificity of S. aureus. Particular clonal lineages are obviously specific for humans (e.g. ST15, ST25, ST45) and other for ruminants (e.g. ST151). MRSA associated with veterinary nosocomial infections (e.g. ST8 and ST254 in horses, ST22 in small animals) very likely have their origin in health care facilities. MRSA ST398 which became first known from widespread colonization in industrially raised pigs seems to have a limited host specificity and is able to colonize and to cause infections in various hosts. Mechanisms of host adaptation and their genomic background are poorly understood so far.
耐甲氧西林金黄色葡萄球菌（MRSA）在马、宠物和生产性家畜等动物中的出现引起了人们对其可能的人类起源以及金黄色葡萄球菌宿主特异性的关注。某些克隆谱系显然对人类具有特异性（例如 ST15、ST25、ST45），而其他谱系则对反刍动物具有特异性（例如 ST151）。与兽医医院感染相关的 MRSA（例如马中的 ST8 和 ST254，小动物中的 ST22）很可能起源于医疗机构。MRSA ST398 最初是从广泛定植于工业化养殖猪中发现的，它似乎具有有限的宿主特异性，能够定植并引起各种宿主的感染。宿主适应的机制及其基因组背景迄今为止还了解甚少。
