Department of Public Health, Erasmus MC, CA Rotterdam, The Netherlands.
QJM. 2010 Feb;103(2):99-108. doi: 10.1093/qjmed/hcp169. Epub 2009 Dec 11.
Measuring quality of care and ranking hospitals with outcome measures poses two major methodological challenges: case-mix adjustment and variation that exists by chance.
To compare methods for comparing and ranking hospitals that considers these.
The Netherlands Stroke Survey was conducted in 10 hospitals in the Netherlands, between October 2002 and May 2003, with prospective and consecutive enrollment of patients with acute brain ischaemia. Poor outcome was defined as death or disability after 1 year (modified Rankin scale of > or =3). We calculated fixed and random hospital effects on poor outcome, unadjusted and adjusted for patient characteristics. We compared the hospitals using the expected rank, a novel statistical measure incorporating the magnitude and the uncertainty of differences in outcome.
At 1 year after stroke, 268 of the total 505 patients (53%) had a poor outcome. There were substantial differences in outcome between hospitals in unadjusted analysis (chi(2) = 48, 9 df, P < 0.0001). Adjustment for 12 confounders led to halving of the chi(2) (chi(2) = 24). The same pattern was observed in random effects analysis. Estimated performance of individual hospitals changed considerably between unadjusted and adjusted analysis. Further changes were seen with random effect estimation, especially for smaller hospitals. Ordering by expected rank led to shrinkage of the original ranks of 1-10 towards the median rank of 5.5 and to a different order of the hospitals, compared to ranking based on fixed effects.
In comparing and ranking hospitals, case-mix-adjusted random effect estimates and the expected ranks are more robust alternatives to traditional fixed effect estimates and simple rankings.
使用结果衡量标准来衡量医疗质量并对医院进行排名存在两个主要的方法学挑战:病例组合调整和存在的偶然变异。
比较考虑这些因素的比较和排名医院的方法。
荷兰卒中调查于 2002 年 10 月至 2003 年 5 月在荷兰的 10 家医院进行,前瞻性地连续纳入急性脑缺血患者。不良预后定义为 1 年后死亡或残疾(改良 Rankin 量表>或=3)。我们计算了固定和随机医院对不良预后的影响,未调整和调整了患者特征。我们使用预期排名比较了医院,这是一种新的统计措施,结合了结果差异的幅度和不确定性。
卒中后 1 年,505 例患者中有 268 例(53%)预后不良。未经调整分析中,医院之间的预后存在显著差异(卡方值=48,9 自由度,P<0.0001)。调整 12 个混杂因素后,卡方值减半(卡方值=24)。随机效应分析也观察到了相同的模式。个体医院的估计表现在未经调整和调整分析之间发生了很大变化。随着随机效应估计的进一步变化,特别是对于较小的医院。按预期排名排序导致原始排名 1-10 向中位数排名 5.5 缩小,并与基于固定效应的排名不同。
在比较和排名医院时,病例组合调整的随机效应估计和预期排名是传统固定效应估计和简单排名的更稳健替代方法。