Fu Yu-Shan, Wang Ji-Hung, Lee Chung-Jen, Hsu Bang-Gee
School of Medicine, Tzu Chi University, Hualien.
Division of Cardiology, Buddhist Tzu Chi General Hospital, Hualien.
Ther Clin Risk Manag. 2018 Feb 5;14:231-236. doi: 10.2147/TCRM.S150476. eCollection 2018.
Angiopoietin-like protein 3 (ANGPTL3) plays an important role in lipid metabolism and angiogenesis and is elevated in familial hypercholesterolemia, metabolic syndrome, and insulin resistance. This study aims to evaluate the relationship between the fasting serum ANGPTL3 levels and the aortic augmentation index (AIx) in patients with coronary artery disease (CAD).
Fasting blood samples were obtained from 100 patients with CAD. The AIx was measured using a validated tonometry system (SphygmoCor). The serum ANGPTL3 levels were assessed using a commercial enzyme-linked immunosorbent assay kit.
The aortic AIx values were higher in female patients with CAD (=0.003) than those in male patients with CAD. The univariate linear analysis of the aortic AIx values reveals that the height (=-0.363; <0.001) and body weight (=-0.350; <0.001) were negatively correlated, whereas the age (=0.202; =0.044) and logarithmically transformed ANGPTL3 (log-ANGPTL3, =0.357; <0.001) were positively correlated with the aortic AIx values in patients with CAD. The multivariate forward stepwise linear regression analysis of the factors significantly associated with the aortic AIx revealed that the height (=-0.269; adjusted change=0.123; =0.007) and serum log-ANGPTL3 level (=0.259; adjusted change=0.051; =0.010) were independent predictors of the aortic AIx values in patients with CAD.
The fasting serum ANGPTL3 level positively correlated with the aortic AIx values among patients with CAD.
血管生成素样蛋白3（ANGPTL3）在脂质代谢和血管生成中起重要作用，在家族性高胆固醇血症、代谢综合征和胰岛素抵抗中升高。本研究旨在评估冠状动脉疾病（CAD）患者空腹血清ANGPTL3水平与主动脉增强指数（AIx）之间的关系。
从100例CAD患者中采集空腹血样。使用经过验证的眼压测量系统（SphygmoCor）测量AIx。使用商用酶联免疫吸附测定试剂盒评估血清ANGPTL3水平。
CAD女性患者的主动脉AIx值高于CAD男性患者（=0.003）。对主动脉AIx值的单变量线性分析显示，身高（=-0.363；<0.001）和体重（=-0.350；<0.001）呈负相关，而年龄（=0.202；=0.044）和对数转换后的ANGPTL3（log-ANGPTL3，=0.357；<0.001）与CAD患者的主动脉AIx值呈正相关。对与主动脉AIx显著相关的因素进行多变量向前逐步线性回归分析显示，身高（=-0.269；调整后变化=0.123；=0.007）和血清log-ANGPTL3水平（=0.259；调整后变化=0.051；=0.010）是CAD患者主动脉AIx值的独立预测因素。
CAD患者空腹血清ANGPTL3水平与主动脉AIx值呈正相关。
