Department of Health and Exercise Science, Wake Forest University, Winston-Salem, NC, USA.
Aging Clin Exp Res. 2010 Oct-Dec;22(5-6):383-6. doi: 10.3275/6734. Epub 2009 Dec 14.
Nitric oxide (NO) may play a critical role in facilitating the delivery of blood to active skeletal muscle, ultimately impacting functional health in older adults. Plasma nitrite is a useful marker of vascular NO bioavailability. The aim of the current investigation was to examine the effect of a widely used physical function test on plasma nitrite concentrations in older adults.
Venous blood was drawn before, immediately following, and 10 minutes following the completion of a 400-m walk test. Blood samples were added to heparin and frozen for subsequent analysis of nitrite levels using chemiluminescence.
Twenty six (79±4 yrs) women participated in this study. Plasma nitrite levels decreased approximately 22% from baseline following a 400-m walk. Percent change in plasma nitrite was related to walking speed (r=-0.550, p=0.004).
These data suggest an alteration in plasma nitrite concentration following a functional test which may impact functional health.
一氧化氮（NO）可能在促进血液流向活跃的骨骼肌方面发挥关键作用，最终影响老年人的功能健康。血浆亚硝酸盐是血管中 NO 生物利用度的有用标志物。本研究旨在探讨一项广泛使用的体能测试对老年人血浆亚硝酸盐浓度的影响。
在完成 400 米步行测试前后及 10 分钟时抽取静脉血。将血液样本加入肝素中并冷冻，随后使用化学发光法分析亚硝酸盐水平。
本研究共纳入 26 名女性（79±4 岁）。400 米步行后，血浆中亚硝酸盐水平下降约 22%。血浆中亚硝酸盐的变化百分比与步行速度相关（r=-0.550，p=0.004）。
这些数据表明，功能测试后血浆中亚硝酸盐浓度发生变化，可能会影响功能健康。
