Department of Biochemistry and Biophysics, Program in Molecular Biology and Biotechnology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Cell Adh Migr. 2010 Jan-Mar;4(1):67-71. doi: 10.4161/cam.4.1.10208. Epub 2010 Jan 29.
The glia that reside at the midline of the Drosophila CNS are an important embryonic signaling center and also wrap the axons that cross the CNS. The development of the midline glia (MG) is characterized by migration, ensheathment, subdivision of axon commissures, apoptosis, and the extension of glial processes. All of these events are characterized by cell-cell contact between MG and adjacent neurons. Cell adhesion and signaling proteins that mediate different aspects of MG development and MG-neuron interactions have been identified. This provides a foundation for ultimately obtaining an integrated picture of how the MG assemble into a characteristic axonal support structure in the CNS.
位于果蝇中枢神经系统中线的神经胶质细胞是一个重要的胚胎信号中心，同时也包裹着穿过中枢神经系统的轴突。中线神经胶质细胞（MG）的发育特征是迁移、包裹、轴突连合的细分、凋亡和神经胶质突起的延伸。所有这些事件的特征是 MG 与相邻神经元之间的细胞-细胞接触。已经鉴定出介导 MG 发育和 MG-神经元相互作用不同方面的细胞黏附蛋白和信号蛋白。这为最终获得一个完整的图景奠定了基础，即 MG 如何组装成中枢神经系统中具有特征性的轴突支持结构。
