Pain & Fatigue Study Center, Department of Neurosciences, UMDNJ-New Jersey Medical School, Newark, NJ 07103, USA.
Med Sci Sports Exerc. 2010 Jan;42(1):16-22. doi: 10.1249/MSS.0b013e3181b11bc7.
Patients with chronic fatigue syndrome (CFS) report that exertion produces dramatic symptom worsening. We hypothesized this might be due to the exacerbation of an underlying sleep disorder, which we have previously demonstrated to exist.
Female patients with CFS and matched healthy controls with no evidence of major depressive disorder were studied with overnight polysomnography on a baseline night and on a night after their performance of a maximal exercise test.
CFS patients as a group had evidence for disturbed sleep compared with controls. Although exercise improved sleep for healthy subjects, it did not do this for the group as a whole. When we stratified the sample on the basis of self-reported sleepiness after a night's sleep, the patient group with reduced morning sleepiness showed improvement in sleep structure, whereas those with increased morning sleepiness continued to show evidence for sleep disruption.
Sleep is disturbed in CFS patients as a group, but exercise does not exacerbate this sleep disturbance. Approximately half the patients studied actually sleep better after exercise. Therefore, activity-related symptom worsening is not caused by worsened sleep.
慢性疲劳综合征 (CFS) 患者报告称，劳累会导致症状明显恶化。我们假设这可能是由于潜在睡眠障碍的加剧，我们之前已经证明这种障碍确实存在。
对患有 CFS 的女性患者和没有明显重性抑郁障碍的匹配健康对照者进行了整夜多导睡眠图检查，一次在基线夜，另一次在进行最大运动试验后的夜间。
CFS 患者组与对照组相比，睡眠存在紊乱。尽管运动改善了健康受试者的睡眠，但对整个组却没有效果。当我们根据一夜睡眠后的自我报告的困倦程度对样本进行分层时，早晨困倦减轻的患者组的睡眠结构得到了改善，而早晨困倦增加的患者继续表现出睡眠紊乱的证据。
CFS 患者组的睡眠受到干扰，但运动不会加重这种睡眠障碍。研究中约有一半患者实际上在运动后睡眠质量更好。因此，与活动相关的症状恶化不是由睡眠恶化引起的。
