生长障碍中身体水分测量：生物电阻抗和皮褶厚度技术与同位素稀释法的比较
Body water measurement in growth disorders: a comparison of bioelectrical impedance and skinfold thickness techniques with isotope dilution.
作者信息
Gregory J W, Greene S A, Scrimgeour C M, Rennie M J
机构信息
Department of Child Health, University of Dundee.
出版信息
Arch Dis Child. 1991 Feb;66(2):220-2. doi: 10.1136/adc.66.2.220.
Total body water was estimated as part of the assessment of body composition in children with growth disorders, using the newly commercially available method of bioelectrical impedance. This was undertaken to compare the precision and accuracy of the results with those derived from skinfold thickness against measurement of stable isotopically labelled water (H2(18)O) dilution as a standard. The comparisons were carried out to see to what extent the impedance method could be applied with confidence to assessment of children with growth disorders. Total body water was derived from impedance (I) using an association with height (Ht2/I). Impedance and skinfold thickness estimates of total body water were equally precise when compared with values obtained from H2(18)O dilution (limits of agreement -1.9 to +1.3 and -1.7 to +2.0 kg respectively). The mean intraobserver coefficient of variation for repeat measurements of impedance was 0.9% compared with 4.6% for skinfold thickness with an interobserver coefficient of variation for impedance of 2.8%. Bioelectrical impedance estimation of body composition is likely to be of value in the growth clinic when expertise in measurement of skinfold thickness is limited or repeated measurements are to be undertaken by different observers.
作为对生长障碍儿童身体成分评估的一部分，采用新上市的生物电阻抗方法估算总体水含量。这样做是为了将结果的精密度和准确性与通过皮褶厚度测量得出的结果进行比较，并以稳定同位素标记水（H2(18)O）稀释法测量作为标准。进行这些比较是为了确定阻抗法在多大程度上能够可靠地应用于生长障碍儿童的评估。总体水含量通过阻抗（I）与身高（Ht2/I）的关联得出。与通过H2(18)O稀释法获得的值相比，阻抗法和皮褶厚度法对总体水含量的估计同样精确（一致性界限分别为-1.9至+1.3千克和-1.7至+2.0千克）。阻抗重复测量的观察者内变异系数均值为0.9%，而皮褶厚度为4.6%，阻抗的观察者间变异系数为2.8%。当皮褶厚度测量方面的专业知识有限或由不同观察者进行重复测量时，生物电阻抗法对身体成分的估计在生长诊所可能具有价值。
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