Duke University, Durham, NC, USA.
Int J Nanomedicine. 2009;4:277-82.
A long circulating liposomal, nanoscale blood pool agent encapsulating traditional iodinated contrast agent (65 mg I/mL) was used for micro-computed tomography (CT) imaging of rats implanted with R3230AC mammary carcinoma. Three-dimensional vascular architecture of tumors was imaged at 100-micron isotropic resolution. The image data showed good qualitative correlation with pathologic findings. The approach holds promise for studying tumor angiogenesis and for evaluating anti-angiogenesis therapies.
一种长循环的脂质体、纳米级血池造影剂，其内包裹着传统的碘造影剂（65mgI/mL），用于检测植入 R3230AC 乳腺癌的大鼠的微计算机断层扫描（CT）成像。肿瘤的三维血管结构以 100 微米各向同性分辨率成像。图像数据与病理发现具有良好的定性相关性。该方法有望用于研究肿瘤血管生成和评估抗血管生成治疗。
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