艰难梭菌结肠炎
Clostridium difficile colitis.
作者信息
Trudel Judith L
机构信息
Division of Colon and Rectal Surgery, Department of Surgery, University of Minnesota, St. Paul, MN 55104, USA.
出版信息
Clin Colon Rectal Surg. 2007 Feb;20(1):13-7. doi: 10.1055/s-2007-970195.
Abstract
Clostridium difficile enterocolitis is endemic in most modern hospitals. The spectrum of clinical presentation varies from the asymptomatic carrier state to fulminant colitis with toxic megacolon and perforation. Highly toxigenic and lethal strains of C. difficile have emerged worldwide. Medical treatment consists of discontinuing the precipitating antibiotic, supportive measures and bowel rest, and antibiotic treatment with metronidazole or vancomycin. Surgical treatment may be necessary in cases of fulminant disease. Subtotal colectomy with end ileostomy is the operation of choice.
摘要
艰难梭菌性小肠结肠炎在大多数现代医院中呈地方性流行。临床表现范围从无症状携带状态到伴有中毒性巨结肠和穿孔的暴发性结肠炎。高毒力和致死性的艰难梭菌菌株已在全球出现。医学治疗包括停用引发疾病的抗生素、采取支持措施和肠道休息，以及用甲硝唑或万古霉素进行抗生素治疗。对于暴发性疾病病例，可能需要进行手术治疗。行回肠末段造口术的结肠次全切除术是首选术式。
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