School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, P.R. China.
Nat Prod Res. 2010;24(1):81-5. doi: 10.1080/14786410902836701.
A new anthraquinone compound, 5-acetyl-2-methoxy-1,4,6-trihydroxy-anthraquinone (1), together with four known naphthoquinones (2-5), were isolated from the culture of the mangrove fungus (No. b77). All the isolated compounds (1-5) and the acetyl derivative (1a) were established by comprehensive analysis of the spectral data, especially 1D- and 2D-NMR (HMQC and HMBC) spectra. In the primary bioassays, compound 3 showed strong inhibitory effects on the growth of hepG2 and hep2 cells, with IC(50) values of 1.0 and 2.5 microg mL(-1), respectively.
从红树林真菌（No. b77）的培养物中分离得到一种新的蒽醌化合物 5-乙酰基-2-甲氧基-1,4,6-三羟基蒽醌（1），以及四个已知的萘醌化合物（2-5）。所有分离得到的化合物（1-5）和乙酰衍生物（1a）均通过光谱数据分析，特别是 1D-和 2D-NMR（HMQC 和 HMBC）图谱综合分析确定。在初步的生物测定中，化合物 3 对 hepG2 和 hep2 细胞的生长表现出强烈的抑制作用，其 IC50值分别为 1.0 和 2.5 μg mL-1。
