一种新型蒽醌衍生物来自海洋内生真菌 Fusarium sp. (No. b77)。
A new anthraquinone derivative from the marine endophytic fungus Fusarium sp. (No. b77).
机构信息
School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, P.R. China.
出版信息
Nat Prod Res. 2010;24(1):81-5. doi: 10.1080/14786410902836701.
A new anthraquinone compound, 5-acetyl-2-methoxy-1,4,6-trihydroxy-anthraquinone (1), together with four known naphthoquinones (2-5), were isolated from the culture of the mangrove fungus (No. b77). All the isolated compounds (1-5) and the acetyl derivative (1a) were established by comprehensive analysis of the spectral data, especially 1D- and 2D-NMR (HMQC and HMBC) spectra. In the primary bioassays, compound 3 showed strong inhibitory effects on the growth of hepG2 and hep2 cells, with IC(50) values of 1.0 and 2.5 microg mL(-1), respectively.
从红树林真菌（No. b77）的培养物中分离得到一种新的蒽醌化合物 5-乙酰基-2-甲氧基-1,4,6-三羟基蒽醌（1），以及四个已知的萘醌化合物（2-5）。所有分离得到的化合物（1-5）和乙酰衍生物（1a）均通过光谱数据分析，特别是 1D-和 2D-NMR（HMQC 和 HMBC）图谱综合分析确定。在初步的生物测定中，化合物 3 对 hepG2 和 hep2 细胞的生长表现出强烈的抑制作用，其 IC50值分别为 1.0 和 2.5 μg mL-1。
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