Research Centre for Natural Medicinal Chemistry, College of Science, Northwest A&F University, Yangling, Shaanxi, China.
Bioorg Med Chem Lett. 2011 Mar 15;21(6):1887-9. doi: 10.1016/j.bmcl.2010.12.043. Epub 2010 Dec 10.
A new isocoumarin derivative named fusariumin (1), together with two known related resorcylic acid lactones aigialomycin D (2) and pochonin N (3), has been isolated from the cultures of Fusarium sp. LN-10, an endophytic fungus originated from the leaves of Melia azedarach. Their structures were established on the basis of extensive spectroscopic analyzes including 1D- and 2D- NMR ((1)H-(1)H COSY, HSQC, HMBC, and NOESY) experiments. Compounds 1-3 displayed significant growth inhibitory activity against the brine shrimp (Artemia salina).
从内生真菌 Fusarium sp. LN-10 的培养物中分离得到一种新的异香豆素衍生物，命名为 fusariumin (1)，以及两种已知的相关 resorcylic acid lactones aigialomycin D (2) 和 pochonin N (3)。这些化合物的结构是基于广泛的光谱分析确定的，包括 1D 和 2D-NMR ((1)H-(1)H COSY、HSQC、HMBC 和 NOESY)实验。化合物 1-3 对卤虫（Artemia salina）表现出显著的生长抑制活性。
