切分：胞质分裂的化学生物学。
Making the cut: the chemical biology of cytokinesis.
机构信息
Dana-Farber Cancer Institute and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.
出版信息
ACS Chem Biol. 2010 Jan 15;5(1):79-90. doi: 10.1021/cb900256m.
Abstract
Cytokinesis is the last step in the cell cycle, where daughter cells finally separate. It is precisely regulated in both time and space to ensure that each daughter cell receives an equal share of DNA and other cellular materials. Chemical biology approaches have been used very successfully to study the mechanism of cytokinesis. In this review, we discuss the use of small molecule probes to perturb cytokinesis, as well as the role naturally occurring small molecule metabolites such as lipids play during cytokinesis.
摘要
有丝分裂是细胞周期的最后一步，在此过程中，子细胞最终分离。它在时间和空间上都受到精确的调控，以确保每个子细胞都能获得等量的 DNA 和其他细胞物质。化学生物学方法已被成功用于研究有丝分裂的机制。在这篇综述中，我们讨论了使用小分子探针来干扰有丝分裂，以及天然存在的小分子代谢物（如脂质）在有丝分裂过程中所起的作用。
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