Inserm, U846, Stem Cell and Brain Research Institute, 69500 Bron, France.
J Neurosci. 2009 Dec 16;29(50):15675-83. doi: 10.1523/JNEUROSCI.4943-09.2009.
Feedback monitoring and adaptation of performance involve a medial reward system including medial frontal cortical areas, the medial striatum, and the dopaminergic system. A considerable amount of data has been obtained on frontal surface feedback-related potentials (FRPs) in humans and on the correlate of outcome monitoring with single unit activity in monkeys. However, work is needed to bridge knowledge obtained in the two species. The present work describes FRPs in monkeys, using chronic recordings, during a trial and error task. We show that frontal FRPs are differentially sensitive to successes and failures and can be observed over long-term periods. In addition, using the dopamine antagonist haloperidol we observe a selective effect on FRP amplitude that is absent for pure sensory-related potentials. These results describe frontal dopaminergic-dependent FRPs in monkeys and corroborate a human-monkey homology for performance monitoring signals.
反馈监测和性能适应涉及包括内侧前额皮质区域、内侧纹状体和多巴胺能系统的一个奖励系统。已经在人类中获得了大量关于额面反馈相关电位（FRP）的资料，以及关于猴子中与结果监测相关的单单位活动的资料。然而，需要开展工作来弥合在这两个物种中获得的知识。本工作使用慢性记录，在一个试错任务中描述了猴子的 FRP。我们表明，额 FRP 对成功和失败有不同的敏感性，可以在长时间内观察到。此外，使用多巴胺拮抗剂氟哌啶醇，我们观察到对 FRP 幅度的选择性影响，而对于纯感觉相关电位则不存在这种影响。这些结果描述了猴子中的额部多巴胺能依赖的 FRP，并证实了猴子的行为监测信号与人猴同源性。
