Belda Eliseo, Blissitt Karen J, Duncan Juliet C, Laredo Francisco G, Escobar Gil de Montes Mayte, Clutton R Eddie
Departamento de Medicina y Cirugía Animal, Hospital Clínico Veterinario, Universidad de Murcia, Murcia, Spain.
Vet Anaesth Analg. 2010 Jan;37(1):25-34. doi: 10.1111/j.1467-2995.2009.00507.x.
To record the bispectral index (BIS) when horses moved during either halothane or sevoflurane anaesthesia and when they made volitional movements during recovery from these anaesthetics.
Randomized prospective clinical study.
Twenty-five client-owned horses undergoing surgery aged 8.8 (+/- 5.3; 1-19) years (mean +/- SD; range).
Baseline BIS values were recorded before pre-anaesthetic medication (BIS(B)) and during anaesthesia (BIS(A)) maintained with halothane (group H; n = 12) or sevoflurane (group S; n =13) at approximately 0.8-0.9 x minimum alveolar concentrations (MAC). Bispectral indices were recorded during the surgery when unexpected movement occurred (BIS(MA)), during recovery when the first movement convincingly associated with consciousness was observed (BIS(M1)) and once sternal recumbency was achieved (BIS(ST)).
No significant difference in BIS(M1) was found between halothane- (85 +/- 7; 75-93) and sevoflurane- (87 +/- 10; 70-98) anaesthetized horses although BIS(A) was significantly (p = 0.0002) lower in group S (62 +/- 7; 53-72) than group H (74 +/- 7; 60-84). Differences between BIS(M1) and BIS(A) were significant in sevoflurane (p = 0.00001) and halothane recipients (p = 0.002) but were greater in group S (25 +/- 9; 4-38) compared with group H (12 +/- 10; -9-25). In six of eight horses, BIS(MA) values ranged between those recorded during anaesthesia and at first movement.
Bispectral indices appear to approximate levels of unconsciousness, suggesting that monitoring the BIS may assist equine anaesthesia. However, it does not predict intra-operative movement.
记录马匹在氟烷或七氟醚麻醉期间移动时以及从这些麻醉中恢复过程中自主运动时的脑电双频指数（BIS）。
随机前瞻性临床研究。
25匹客户拥有的接受手术的马匹，年龄为8.8（±5.3；1 - 19）岁（平均值±标准差；范围）。
在麻醉前用药前（BIS(B)）以及用氟烷（H组；n = 12）或七氟醚（S组；n = 13）维持麻醉期间（BIS(A)），以大约0.8 - 0.9倍最低肺泡浓度（MAC）记录基线BIS值。在手术期间意外移动发生时（BIS(MA)）、恢复期间观察到与意识有明确关联的首次移动时（BIS(M1)）以及达到胸卧姿势时（BIS(ST)）记录脑电双频指数。
氟烷麻醉（85 ± 7；75 - 93）和七氟醚麻醉（87 ± 10；70 - 98）的马匹之间，BIS(M1)未发现显著差异，尽管S组（62 ± 7；53 - 72）的BIS(A)显著低于H组（74 ± 7；60 - 84）（p = 0.0002）。七氟醚组（p = 0.00001）和氟烷组（p = 0.002）中，BIS(M1)与BIS(A)之间的差异显著，但S组（25 ± 9；4 - 38）比H组（12 ± 10； - 9 - 25）更大。在8匹马中的6匹，BIS(MA)值介于麻醉期间和首次移动时记录的值之间。
脑电双频指数似乎接近无意识水平，表明监测BIS可能有助于马的麻醉。然而，它不能预测术中的移动。
