Department of Biochemistry, Faculty of Science, Annamalai University, Annamalainagar, Tamilnadu, India.
Toxicol Mech Methods. 2005;15(3):227-34. doi: 10.1080/15376520590945658.
Alcohol use is contributing to an unprecedented decline in life expectancy. It induces hyperlipidemia when taken at higher concentrations. Alcoholics usually after a heavy binge of alcohols take fried food items normally made up of polyunsaturated fatty acids (PUFAs). The combined ingestion of alcohol and PUFAs is considered to be dangerous and known to result in hyperlipidemic conditions. Previous studies have shown that curcumin, an active principle of turmeric (Curcuma longa), has antihyperlipidemic properties. So in the present work we have synthesized an analog of curcumin and tested the protective role of that synthetic curcuminoid on alcohol and thermally oxidized sunflower oil-induced hyperlipidemia. Male Albino rats of Wistar strain were used for the experimental study. Antihyperlipidemic activity of the synthetic curcuminoid was evaluated by analyzing the levels of lipids (cholesterol, triglycerides [TGs], phospholipids [PLs], and free fatty acids [FFAs]) in different tissues and histopathological changes in the liver. The results showed that the levels of cholesterol, TGs, and FFAs were increased significantly in alcohol, thermally oxidized sunflower oil (Delta PUFA), and alcohol + Delta PUFAs treated groups. Administration of synthetic curcuminoid effectively reduced these levels. The phospholipid (PL) levels, which were decreased in the liver and kidney and increased in the heart in the alcohol, Delta PUFA, and alcohol + Delta PUFA groups, were positively modulated by treatment with synthetic curcuminoid (CA). Our histopathological observations were also in correlation with the biochemical parameters. From the results obtained, we could conclude that the synthetic curcuminoid effectively protects the system against alcohol and Delta PUFA-induced hyperlipidemia and may become an effective therapeutic agent for the treatment of hyperlipidemia.
饮酒导致预期寿命出现前所未有的下降。当浓度较高时，它会引起高血脂。酗酒者通常在大量饮酒后会食用通常由多不饱和脂肪酸（PUFAs）组成的油炸食品。同时摄入酒精和 PUFAs 被认为是危险的，已知会导致高血脂症。先前的研究表明，姜黄素，姜黄（Curcuma longa）的一种活性成分，具有抗高血脂特性。因此，在本工作中，我们合成了姜黄素的类似物，并测试了该合成姜黄素类似物对酒精和热氧化葵花籽油诱导的高血脂症的保护作用。使用 Wistar 品系雄性白化大鼠进行实验研究。通过分析不同组织中的脂质（胆固醇，甘油三酯[TGs]，磷脂[PLs]和游离脂肪酸[FFAs]）水平以及肝脏的组织病理学变化来评估合成姜黄素类似物的抗高血脂活性。结果表明，胆固醇，TG 和 FFA 的水平在酒精，热氧化葵花籽油（Delta PUFAs）和酒精+Delta PUFAs 处理组中显着增加。合成姜黄素类似物的给药有效地降低了这些水平。在酒精，Delta PUFAs 和酒精+Delta PUFAs 组中，肝脏和肾脏中的磷脂（PL）水平降低，心脏中的 PL 水平升高，而合成姜黄素类似物（CA）的治疗则正向调节 PL 水平。我们的组织病理学观察结果也与生化参数相关。从获得的结果中，我们可以得出结论，合成姜黄素类似物可有效保护系统免受酒精和 Delta PUFAs 诱导的高血脂症的侵害，并且可能成为治疗高血脂症的有效治疗剂。
