Department of Biochemistry, Faculty of Science, Annamalai University, Annamalainagar, Tamil Nadu, India.
Toxicol Mech Methods. 2003;13(1):77-81. doi: 10.1080/15376510309825.
The present investigation was undertaken to examine the blood levels of lipid peroxides and the antioxidants superoxide dismutase, catalase, reduced glutathione, glutathione peroxidase, and glutathione-S-transferase in oral precancer, preoperative, postoperative, and recurrent oral cancer patients with age- and sex-matched normal healthy subjects as controls. In patients with oral precancer and oral cancer, enhanced lipid peroxidation was accompanied by antioxidant depletion. These changes were more pronounced in patients with recurrent oral tumors. Twelve weeks after surgery, decreased lipid peroxidation was accompanied by increased antioxidant levels. The results of this study indicate that imbalance in the redox status of oral cancer patients may be due to enhanced lipid peroxidation and compromised antioxidant defenses.
本研究旨在检测口腔癌前病变、术前、术后及复发性口腔癌患者与年龄和性别匹配的正常健康对照者的血液脂质过氧化物水平和抗氧化剂超氧化物歧化酶、过氧化氢酶、还原型谷胱甘肽、谷胱甘肽过氧化物酶和谷胱甘肽-S-转移酶。在口腔癌前病变和口腔癌患者中，增强的脂质过氧化作用伴随着抗氧化剂的消耗。在复发性口腔肿瘤患者中，这些变化更为明显。手术后 12 周，脂质过氧化作用降低，抗氧化剂水平升高。本研究结果表明，口腔癌患者氧化还原状态失衡可能是由于脂质过氧化作用增强和抗氧化防御受损所致。
