Majidi Ziba, Djalali Mahmoud, Javanbakht Mohammad Hasan, Fathi Mojtaba, Zarei Mahnaz, Foladsaz Koorosh
Dept. of Clinical Biochemistry, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.
Dept. of Cellular & Molecular Nutrition, School of Nutritional Sciences & Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Iran J Public Health. 2017 Aug;46(8):1104-1109.
Basal Cell Carcinoma (BCC) is one of the most common skin cancers in the world and that use to lifestyle, increasing chemical pollutions, environmental factors and poor nutrition. The most important cause of this cancer is oxidative stress and free radicals so antioxidant activities for the body are so important. The aim of this study was to determine the variation of zinc and (Malondialdehyde) MDA in BCC patients.
This study has been performed on case and control patients from 2013 to 2014. The samples were collected from cell carcinoma patients at Razi Hospital in Tehran, Iran. We evaluated the level of zinc with the use of Atomic Absorption Spectroscopy (AAS) method. Besides, we evaluated MDA with colorimetric assay.
The concentration of MDA was significantly higher in case group in comparison to control group (=0.001). In addition, case group had lower concentration of zinc than the control group (=0.000). There was no correlation between MDA and body mass index (BMI) and between zinc and BMI.
All the patients with BCC showed a significant MDA serum in comparison with control group. However, significant decrease in zinc serum of the patients was seen that is because of consuming zinc during oxidative stress process so topical use of zinc in the form of 2+ ions could be effective on antioxidant protection against the sun UV radiation.
基底细胞癌（BCC）是世界上最常见的皮肤癌之一，其发病与生活方式、化学污染增加、环境因素及营养不良有关。这种癌症的最重要病因是氧化应激和自由基，因此机体的抗氧化活性非常重要。本研究的目的是确定基底细胞癌患者体内锌和丙二醛（MDA）的变化情况。
本研究于2013年至2014年对病例组和对照组患者进行。样本取自伊朗德黑兰拉齐医院的细胞癌患者。我们使用原子吸收光谱法（AAS）评估锌的水平。此外，我们用比色法评估丙二醛。
病例组丙二醛浓度显著高于对照组（=0.001）。此外，病例组锌浓度低于对照组（=0.000）。丙二醛与体重指数（BMI）之间以及锌与BMI之间均无相关性。
与对照组相比，所有基底细胞癌患者血清丙二醛均显著升高。然而，患者血清锌显著降低，这是因为在氧化应激过程中锌被消耗，因此以2+离子形式局部使用锌可能对抵御太阳紫外线辐射的抗氧化保护有效。
