Ganesan Anuradha, Kumar N Gautham
Reader, Department of Oral Medicine & Radiology, Madha Dental College , Chennai, India .
Reader, Department of Periodontics, Madha Dental College , Chennai, India .
J Clin Diagn Res. 2014 Aug;8(8):ZC55-8. doi: 10.7860/JCDR/2014/10200.4768. Epub 2014 Aug 20.
Oral pre cancer and oral cancer results in lipid peroxidation, and assessment of lipid peroxides in body fluids may give insights into the role of anti oxidants in its management.
The study was conducted to discern the varying levels of lipid peroxides in saliva, serum and tissue in oral pre cancer and oral cancer and also various forms of tobacco usage with sex as an added parameter.
The levels of lipid peroxides were measured in saliva, serum and tissue in a total of 50 patients, 20 belonging to control, and 30 study group in which 10 with oral leukoplakia and 20 with histologically proven oral squamous cell carcinoma (OSCC). The mean value of malondialdehyde (MDA) were also recorded in males and females among the patients with oral leukoplakia and OSCC. Among the study group patients, the levels of MDA were also recorded in habits of smoking and chewing tobacco.
Student's independent t-test, one way ANOVA, Tukey HSD procedure.
Significantly elevated levels of lipid peroxides were seen in saliva, serum and tissue in oral leukoplakia and OSCC when compared to control patients. Among the study group, there were statistically significant increased levels of MDA in OSCC when compared to oral leukoplakia. There was also increase in MDA level in patients with smoking and chewing, but the variations seen in males and females were not very significant.
The results clearly indicate the increase in lipid peroxidation in oral pre cancer and oral cancer with no significant difference between gender groups. The role of saliva as a relatively risk free and reliable, easy to obtain biofuid for diagnostic purposes has been highlighted. Also, since the levels of antioxidants are drastically decreased in carcinogenesis, the importance of anti oxidant supplements in the early stages of the disease has also been elucidated.
口腔癌前病变和口腔癌会导致脂质过氧化，评估体液中的脂质过氧化物可能有助于深入了解抗氧化剂在其治疗中的作用。
本研究旨在探讨口腔癌前病变和口腔癌患者唾液、血清和组织中脂质过氧化物的不同水平，以及各种形式的烟草使用情况，并将性别作为一个附加参数。
共检测了50例患者唾液、血清和组织中的脂质过氧化物水平，其中20例为对照组，30例为研究组，研究组中10例为口腔白斑患者，20例为组织学确诊的口腔鳞状细胞癌（OSCC）患者。还记录了口腔白斑和OSCC患者中男性和女性的丙二醛（MDA）平均值。在研究组患者中，还记录了吸烟和咀嚼烟草习惯患者的MDA水平。
学生独立t检验、单因素方差分析、Tukey HSD检验。
与对照组患者相比，口腔白斑和OSCC患者的唾液、血清和组织中脂质过氧化物水平显著升高。在研究组中，与口腔白斑相比，OSCC患者的MDA水平在统计学上显著升高。吸烟和咀嚼烟草的患者MDA水平也有所升高，但男性和女性之间的差异不太显著。
结果清楚地表明口腔癌前病变和口腔癌中脂质过氧化增加，不同性别组之间无显著差异。强调了唾液作为一种相对无风险、可靠且易于获取的生物流体在诊断中的作用。此外，由于致癌过程中抗氧化剂水平急剧下降，也阐明了在疾病早期补充抗氧化剂的重要性。
