Cao Chun-ge, Wang Hong-yu, Xue Wen-sheng, Han Ji-ling, Zhang Xiao-min
Department of Cardiology, Second Clinical Medical College, Shanxi Medical University, Taiyuan 030001, China.
Zhonghua Xin Xue Guan Bing Za Zhi. 2009 Aug;37(8):712-5.
Ambulatory arterial stiffness index (AASI) has been recently proposed to reflect the dynamic relation between diastolic and systolic blood pressure throughout the whole day. The aim of our study was to investigate the change in AASI with advancing age and the correlation with 24 hours pulse pressure (24 h PP) in healthy individuals.
246 healthy subjects [mean age (59.7 +/- 14.6) years, women 38.6%] underwent 24 hours ambulatory blood pressure monitoring (ABPM) in normal life style. The blood pressure recordings, heart rate (HR), mean arterial pressure (MAP) and pulse pressure (PP) were analyzed simultaneously by computer for every 30 minutes during 6:00 am-22:00 pm and every 60 minutes during 22:00 pm-6:00 am. Using all the blood pressure recordings, we plotted diastolic against systolic blood pressure from each individuals and calculated the regression slope. AASI was derived from 1 minus this regression slope.
In 246 healthy individuals, AASI increased with age. Among the healthy individuals, the 95th percentile of AASI was 0.56, the upper boundary of the 95% prediction interval of AASI in relation to age were 0.49 at 20 - 39 years, 0.59 at 40 - 59 years, 0.69 at 60 - 79 years, 0.79 at > or = 80 years. The correlation coefficient between AASI and 24 h PP was 0.497 (P < 0.01). AASI linearly increased with age in healthy individuals, whereas the relation between pulse pressure and age was curvilinear.
AASI as a index reflecting blood pressure relationship, manifested the corresponding change with advancing age. The correlation between AASI and traditional index 24 h PP indicated AASI as a new measure of arterial stiffness.
动态动脉硬化指数（AASI）最近被提出用于反映全天舒张压和收缩压之间的动态关系。我们研究的目的是调查健康个体中AASI随年龄增长的变化以及与24小时脉压（24 h PP）的相关性。
246名健康受试者[平均年龄（59.7±14.6）岁，女性占38.6%]在正常生活方式下接受了24小时动态血压监测（ABPM）。在上午6:00至晚上22:00期间，每30分钟通过计算机同时分析血压记录、心率（HR）、平均动脉压（MAP）和脉压（PP）；在晚上22:00至上午6:00期间，每60分钟分析一次。利用所有血压记录，我们绘制了每个个体的舒张压与收缩压关系图，并计算回归斜率。AASI由1减去该回归斜率得出。
在246名健康个体中，AASI随年龄增长而增加。在健康个体中，AASI的第95百分位数为0.56，AASI与年龄相关的95%预测区间的上限在20 - 39岁时为0.49，40 - 59岁时为0.59，60 - 79岁时为0.69，≥80岁时为0.79。AASI与24 h PP之间的相关系数为0.497（P < 0.01）。在健康个体中，AASI随年龄呈线性增加，而脉压与年龄的关系呈曲线。
AASI作为反映血压关系的指标，随年龄增长呈现相应变化。AASI与传统指标24 h PP之间的相关性表明AASI是一种新的动脉僵硬度测量指标。
