Department of Otorhinolaryngology-Head and Neck Surgery, Chung-Ang University College of Medicine, Seoul, Korea.
Yonsei Med J. 2012 Sep;53(5):999-1004. doi: 10.3349/ymj.2012.53.5.999.
Vascular disorders and viral infections are considered the main causes of sudden hearing loss (SHL), although its pathogenesis remain unclear. Treatments include carbogen inhalation and lipo-prostaglandin E1 (lipo-PGE1), both of which have circulation-enhancing effects. We investigated the effectiveness of carbogen inhalation and lipo-PGE1 in SHL.
This retrospective review included 202 patients with idiopathic SHL who visited our clinic within 14 days of symptom onset between January 2006 and June 2010. All patients received oral prednisolone for 10 days. Of the 202 patients, 44 received no additional treatment, 106 received additional carbogen inhalation, and 52 received additional lipo-PGE1. Hearing improvement was measured using Siegel's criteria.
Overall recovery rates were 67.9% in the carbogen group, 53.8% in the lipo-PGE1 group, and 52.3% in the steroid-only control group (p=0.097). Limited to type 1 and type 2 categories of Sigels's criteria, the carbogen group had a significantly higher recovery rate (53.8%) than the lipo-PGE1 group (26.9%) and the steroid-only control group (38.6%) (p=0.005).
Carbogen inhalation added to steroid was a more effective treatment than lipo-PGE1 added to steroid or steroid alone in patients with SHL.
血管病变和病毒感染被认为是突发性聋（SHL）的主要原因，尽管其发病机制仍不清楚。治疗包括碳氧吸入和脂前列腺素 E1（lipo-PGE1），两者均具有改善循环的作用。我们研究了碳氧吸入和脂前列腺素 E1 在 SHL 中的疗效。
这是一项回顾性研究，纳入了 202 例 2006 年 1 月至 2010 年 6 月就诊于我院的发病 14 天内的特发性 SHL 患者。所有患者均接受了 10 天的泼尼松龙口服治疗。202 例患者中，44 例未接受额外治疗，106 例接受了额外的碳氧吸入，52 例接受了额外的脂前列腺素 E1 治疗。采用 Siegel 的标准评估听力改善情况。
碳氧组的总恢复率为 67.9%，脂前列腺素 E1 组为 53.8%，单纯激素组为 52.3%（p=0.097）。局限于 Sigels 标准的 1 型和 2 型，碳氧组的恢复率（53.8%）显著高于脂前列腺素 E1 组（26.9%）和单纯激素组（38.6%）（p=0.005）。
在 SHL 患者中，与脂前列腺素 E1 联合激素或单纯激素治疗相比，激素联合碳氧吸入治疗更为有效。
