Department of Surgery, Shanghai Jiaotong University Affiliated Ruijin Hospital, Shanghai, People’s Republic of China.
Curr Drug Targets. 2013 Sep;14(10):1192-202. doi: 10.2174/13894501113149990192.
The transcription factor Forkhead box protein M1 (FOXM1) is overexpressed in the majority of cancer patients. This overexpression is implicated to play a role in the pathogenesis, progression, and metastasis of cancer. This important role of FOXM1 demonstrates its significance to cancer therapy. MicroRNAs (miRNAs) are small noncoding, endogenous, single-stranded RNAs that are pivotal posttranscriptional gene expression regulators. MiRNAs aberrantly expressed in cancer cells have important roles in tumorigenesis and progression. Currently, miRNAs are being studied as diagnostic and prognostic biomarkers and therapeutic tools for cancer. The rapid discovery of many target miRNAs and their relevant pathways has contributed to the development of miRNA-based therapeutics for cancer. In this review, we summarize the latest and most significant findings on FOXM1 and miRNA involvement in cancer development and describe the role/roles of miRNA/FOXM1 signaling pathways in cancer initiation and progression. Targeting FOXM1 via regulation of miRNA expression may have a role in cancer treatment, although the miRNA delivery method remains the key challenge to the establishment of this novel therapy.
转录因子叉头框蛋白 M1（FOXM1）在大多数癌症患者中过度表达。这种过表达被认为在癌症的发病机制、进展和转移中起作用。FOXM1 的重要作用表明其对癌症治疗的重要性。微小 RNA（miRNA）是小的非编码、内源性、单链 RNA，是转录后基因表达调控的关键。在癌细胞中异常表达的 miRNA 在肿瘤发生和进展中具有重要作用。目前，miRNA 被作为癌症的诊断和预后生物标志物以及治疗工具进行研究。许多靶 miRNA 及其相关途径的快速发现促进了 miRNA 为基础的癌症治疗方法的发展。在这篇综述中，我们总结了关于 FOXM1 和 miRNA 参与癌症发生和发展的最新和最重要的发现，并描述了 miRNA/FOXM1 信号通路在癌症起始和进展中的作用。通过调节 miRNA 表达靶向 FOXM1 可能在癌症治疗中发挥作用，尽管 miRNA 递送方法仍然是建立这种新疗法的关键挑战。
