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糖存在时磷脂酰胆碱膜层凝胶-流态转变的动力学。

Kinetics of the lamellar gel-fluid transition in phosphatidylcholine membranes in the presence of sugars.

机构信息

Applied Physics, RMIT University, Melbourne, Vic 3001, Australia.

出版信息

Chem Phys Lipids. 2010 Feb;163(2):236-42. doi: 10.1016/j.chemphyslip.2009.12.001. Epub 2009 Dec 16.

DOI:10.1016/j.chemphyslip.2009.12.001
PMID:20025858
Abstract

Phase diagrams are presented for dipalmitoylphosphatidylcholine (DPPC) in the presence of sugars (sucrose) over a wide range of relative humidities (RHs). The phase information presented here, determined by small angle X-ray scattering (SAXS), is shown to be consistent with previous results achieved by differential scanning calorimetry (DSC). Both techniques show a significant effect of sucrose concentration on the phase behaviour of this phospholipid bilayer. An experimental investigation into the effect of sugars on the kinetic behaviour of the gel to fluid transition is also presented showing that increasing the sugar content appears to slightly increase the rate at which the transition occurs.

摘要

呈现了二棕榈酰磷脂酰胆碱(DPPC)在蔗糖存在下的相图,相对湿度(RH)范围很宽。这里呈现的相信息是通过小角 X 射线散射(SAXS)确定的,与通过差示扫描量热法(DSC)获得的先前结果一致。这两种技术都显示出蔗糖浓度对这种磷脂双层相行为的显著影响。还进行了一项关于糖对凝胶到流态转变动力学行为影响的实验研究,结果表明,增加糖含量似乎略微增加了转变发生的速度。

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