Departmento de Parasitologia, Microbiologia e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Juiz de Fora, Juiz de Fora, MG, Brasil.
Mem Inst Oswaldo Cruz. 2009 Nov;104(7):1039-41. doi: 10.1590/s0074-02762009000700018.
Chemokines recruit and activate leukocytes, assisting granuloma formation. Herein, we evaluated plasma chemokines in patients with active tuberculosis (ATB) and after completing treatment (TTB) and compared them to BCG-vaccinated healthy controls (HC). Levels of chemokines were measured by cytometric bead array. Levels of CXCL8, CXCL9 and CXCL10 were higher in ATB patients compared to HC, but they decreased in TTB. Levels of CCL2 and CCL5 in ATB patients were similar to those observed in HC. Thus, the high levels of CXC-chemokines detected during ATB, which can modulate the trafficking of immune cells from the periphery to the site of infection, were reversed by anti-mycobacterial treatment.
趋化因子募集并激活白细胞，协助肉芽肿形成。在此，我们评估了活动性肺结核 (ATB) 患者和治疗完成后 (TTB) 的血浆趋化因子，并将其与卡介苗 (BCG) 接种的健康对照 (HC) 进行比较。通过流式细胞术检测趋化因子水平。与 HC 相比，ATB 患者的 CXCL8、CXCL9 和 CXCL10 水平更高，但在 TTB 中降低。ATB 患者的 CCL2 和 CCL5 水平与 HC 观察到的水平相似。因此，ATB 期间检测到的高水平 CXC-趋化因子可调节免疫细胞从外周向感染部位的迁移，抗分枝杆菌治疗可逆转这种情况。
