Department of Neurology and Neurosurgery, University of Tartu, Estonia.
Acta Neurol Scand. 2010 Apr;121(4):237-43. doi: 10.1111/j.1600-0404.2009.01189.x. Epub 2009 Dec 17.
To identify biomarkers supporting the clinical diagnosis of manganism in patients several years after exposure to manganese (Mn).
Neurophysiological examinations, magnetic resonance imaging (MRI), single-photon emission computed tomography and fluorodeoxyglycose (FDG) positron emission tomography were performed in four former ephedrone addicts with extrapyramidal symptoms.
Peripheral nervous system was not affected. No patients had reduced uptake of (123)I Ioflupane in the striatum. MRI signal intensities were slightly changed in the basal ganglia. All patients showed a widespread, but not uniform, pathological pattern of FDG uptake with changes mainly located to the central part of the brain including the basal ganglia and the surrounding white matter.
Presynaptic neurons in the nigrostriatal pathway are intact in Mn-induced parkinsonism after prolonged abstinence from ephedrone. The diagnosis is principally based on clinical signs and the history of drug abuse.
在暴露于锰 (Mn) 多年后，鉴定支持对锰中毒患者进行临床诊断的生物标志物。
对 4 名有锥体外系症状的前冰毒成瘾者进行了神经生理学检查、磁共振成像 (MRI)、单光子发射计算机断层扫描和氟脱氧葡萄糖 (FDG) 正电子发射断层扫描。
周围神经系统未受影响。没有患者在纹状体中摄取 (123)I Ioflupane 减少。基底节的 MRI 信号强度略有改变。所有患者均表现出广泛但不均匀的 FDG 摄取病理性模式，改变主要位于大脑中央部分，包括基底节和周围白质。
在长期戒断冰毒后，由 Mn 引起的帕金森病中，黑质纹状体通路的突触前神经元完整。该诊断主要基于临床症状和药物滥用史。
