与甲卡西酮（麻黄酮）滥用相关的锰诱导型帕金森症。
Manganese-induced Parkinsonism associated with methcathinone (Ephedrone) abuse.
作者信息
de Bie Rob M A, Gladstone Richard M, Strafella Antonio P, Ko Ji-Hyun, Lang Anthony E
机构信息
Movement Disorder Center, University of Toronto, Ontaio, Canada.
出版信息
Arch Neurol. 2007 Jun;64(6):886-9. doi: 10.1001/archneur.64.6.886.
BACKGROUND
Manganese intoxication may lead to a levodopa-resistant, akinetic-rigid syndrome. A new form of presumed manganese poisoning has been reported in drug-addicted persons from Russia, Ukraine, and Estonia who have intravenously injected self-prepared methcathinone hydrochloride (Ephedrone).
PATIENT
A 36-year-old man from Azerbaijan with hepatitis C and only modest hepatic synthetic dysfunction developed rapid-onset, levodopa-resistant parkinsonism with profound hypophonia.
CONCLUSION
Ephedronic encephalopathy outside the region of the former Soviet Union may become a more widespread public health problem as a result of global travel and the easy availability of the recipe for synthesis of methcathinone on the Internet.
背景
锰中毒可能导致左旋多巴抵抗性的运动不能-强直综合征。据报道，在俄罗斯、乌克兰和爱沙尼亚的吸毒者中出现了一种新形式的疑似锰中毒，这些人静脉注射自制的盐酸去甲伪麻黄碱（麻黄酮）。
患者
一名来自阿塞拜疆的36岁男子，患有丙型肝炎，仅有轻度肝脏合成功能障碍，出现了快速起病的、左旋多巴抵抗性帕金森综合征，并伴有严重的声音低微。
结论
由于全球旅行以及互联网上合成去甲伪麻黄碱配方易于获取，前苏联地区以外的麻黄碱脑病可能会成为一个更广泛的公共卫生问题。
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