Sanotsky Yanush, Lesyk Roman, Fedoryshyn Lyudmyla, Komnatska Iryna, Matviyenko Yuriy, Fahn Stanley
Department of Neurology, Lviv Regional Clinical Hospital, Lviv, Ukraine.
Mov Disord. 2007 Jul 15;22(9):1337-43. doi: 10.1002/mds.21378.
We describe the clinical and neuroimaging features of 6 drug-abuse patients with self-inflicted manganese poisoning. The patients injected a home-brewed mixture called "ephedrone" (slang term) that contained manganese to produce an amphetamine-like euphoria. The desired chemical product, phenylpropanoneamine (also called methcathinone), was synthesized from a common-cold-remedy compound using permanganate as the catalyst. Manganese was a by-product in the ephedrone mixture. After months of self-injections, a clinical picture emerged, consisting of apathy, bradykinesia, gait disorder with postural instability, and spastic-hypokinetic dysarthria. There was no response to levodopa. The MRI revealed symmetric hyperintense T1-weighted signals in the basal ganglia, typical of manganese accumulation.
我们描述了6例药物滥用导致自身锰中毒患者的临床和神经影像学特征。这些患者注射了一种自制的名为“麻黄酮”（俚语）的混合物，其中含有锰，以产生类似安非他明的欣快感。所需的化学产物苯丙酮胺（也称为甲卡西酮）是由一种感冒药化合物使用高锰酸盐作为催化剂合成的。锰是麻黄酮混合物中的副产物。经过数月的自我注射后，出现了一种临床症状，包括冷漠、运动迟缓、伴有姿势不稳的步态障碍以及痉挛性运动减少性构音障碍。左旋多巴治疗无效。MRI显示基底神经节T1加权信号对称高强化，这是锰蓄积的典型表现。
