Second Department of Pediatrics, Aristotle University, AHEPA Hospital, Thessaloniki, Greece.
Mycoses. 2010 May;53(3):187-95. doi: 10.1111/j.1439-0507.2009.01814.x. Epub 2009 Dec 17.
Malassezia spp. form part of the normal human cutaneous flora and are implicated in several mild, but recurrent cutaneous diseases, such as pityriasis versicolor, Malassezia folliculitis, seborrhoeic dermatitis, and, with lesser frequency, a range of other dermatological disorders. Malassezia spp. have also been associated with cutaneous and systemic diseases in immunocompromised patients including folliculitis, seborrhoeic dermatitis, catheter-related fungaemia and a variety of deeply invasive infections. In this review, we provide an overview of the epidemiology, risk factors, pathogenesis, clinical manifestations, diagnosis, treatment and outcome of cutaneous and invasive Malassezia infections in immunocompromised patients.
马拉色菌属是人类正常皮肤菌群的一部分,与一些轻度但反复发作的皮肤疾病有关,如花斑糠疹、糠秕马拉色菌毛囊炎、脂溢性皮炎等,并且较少频率地与一系列其他皮肤疾病有关。马拉色菌属也与免疫功能低下患者的皮肤和系统性疾病有关,包括毛囊炎、脂溢性皮炎、导管相关性真菌血症和多种深部侵袭性感染。在这篇综述中,我们提供了免疫功能低下患者皮肤和侵袭性马拉色菌感染的流行病学、危险因素、发病机制、临床表现、诊断、治疗和预后的概述。