McGill University, Montreal, Quebec H3A 1A2, Canada.
Emerg Infect Dis. 2010 Jan;16(1):88-95. doi: 10.3201/eid1601.091118.
Closely related strains of Escherichia coli have been shown to cause extraintestinal infections in unrelated persons. This study tests whether a food reservoir may exist for these E. coli. Isolates from 3 sources over the same time period (2005-2007) and geographic area were compared. The sources comprised prospectively collected E. coli isolates from women with urinary tract infection (UTI) (n = 353); retail meat (n = 417); and restaurant/ready-to-eat foods (n = 74). E. coli were evaluated for antimicrobial drug susceptibility and O:H serotype and compared by using 4 different genotyping methods. We identified 17 clonal groups that contained E. coli isolates (n = 72) from >1 source. E. coli from retail chicken (O25:H4-ST131 and O114:H4-ST117) and honeydew melon (O2:H7-ST95) were indistinguishable from or closely related to E. coli from human UTIs. This study provides strong support for the role of food reservoirs or foodborne transmission in the dissemination of E. coli causing common community-acquired UTIs.
已证实，与大肠埃希菌密切相关的菌株可导致无关联人群发生肠道外感染。本研究旨在检验是否存在这些大肠埃希菌的食物传染源。在同一时期（2005-2007 年）和同一地理区域内，比较了 3 个来源的分离株。这些来源包括前瞻性收集的 353 例尿路感染（UTI）女性的大肠埃希菌分离株、417 例零售肉品和 74 例餐厅/即食食品。采用 4 种不同的基因分型方法评估大肠埃希菌对抗菌药物的敏感性和 O:H 血清型，并进行比较。我们发现了 17 个克隆群，其中包含来自 1 个以上来源的 72 株大肠埃希菌分离株。零售鸡肉（O25:H4-ST131 和 O114:H4-ST117）和蜜瓜（O2:H7-ST95）中的大肠埃希菌与来自人类 UTI 的大肠埃希菌相同或密切相关。本研究有力地支持了食物传染源或食源性传播在引起常见社区获得性 UTI 的大肠埃希菌传播中的作用。
