McMahon Jeremy, Devine John C, McCaul James A, McLellan Douglas R, Farrow Adrian
Regional Maxillofacial Unit Southern General Hospital, 1345 Govan Road Glasgow, G51 4TF, UK.
Br J Oral Maxillofac Surg. 2010 Mar;48(2):84-7. doi: 10.1016/j.bjoms.2009.05.007. Epub 2010 Jan 19.
We evaluated the use of Lugol's iodine in achieving surgical margins free from dysplasia, carcinoma in situ, and invasive carcinoma by an observational study of two series of 50 consecutive patients having resection of oral and oropharyngeal squamous cell carcinoma (SCC) between November 2004 and March 2007. The standard group had resection of the primary tumour with a macroscopic 1cm margin and removal of adjacent visibly abnormal mucosa. The Lugol's iodine group had identical treatment with resection of any adjacent mucosa that did not stain after the application of Lugol's iodine (where this was feasible). In the standard group 16 patients (32%) had dysplasia, carcinoma in situ, or invasive SCC at a surgical margin. In the Lugol's iodine group two patients (4%) had dysplasia or carcinoma in situ; none had invasive SCC. Lugol's iodine is a simple, inexpensive, and apparently effective means of reducing the likelihood of unsatisfactory surgical margins in the resection of oral and oropharyngeal SCC.
通过对2004年11月至2007年3月期间两组各50例连续接受口腔和口咽鳞状细胞癌（SCC）切除术患者的观察性研究，我们评估了卢戈氏碘在实现无发育异常、原位癌和浸润性癌手术切缘方面的应用。标准组对原发性肿瘤进行宏观上1厘米切缘的切除，并切除相邻可见异常黏膜。卢戈氏碘组进行相同治疗，切除应用卢戈氏碘后未染色的任何相邻黏膜（可行时）。标准组有16例患者（32%）手术切缘存在发育异常、原位癌或浸润性SCC。卢戈氏碘组有2例患者（4%）存在发育异常或原位癌；无浸润性SCC患者。卢戈氏碘是一种简单、廉价且显然有效的方法，可降低口腔和口咽SCC切除术中手术切缘不理想的可能性。
