Department of Orthopeadics & Traumatology, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong.
J R Soc Interface. 2010 Jul 6;7(48):1025-31. doi: 10.1098/rsif.2009.0504. Epub 2009 Dec 23.
Boron plays important roles in many life processes including embryogenesis, bone growth and maintenance, immune function and psychomotor skills. Thus, the delivery of boron by the degradation of borate glass is of special interest in biomedical applications. However, the cytotoxicity of borate glass which arises with the rapid release of boron has to be carefully considered. In this study, it was found that the incorporation of strontium into borate glass can not only moderate the rapid release of boron, but also induce the adhesion of osteoblast-like cells, SaOS-2, thus significantly increasing the cyto-compatibility of borate glass. The formation of multilayers of apatite with porous structure indicates that complete degradation is optimistic, and the spread of SaOS-2 covered by apatite to form a sandwich structure may induce bone-like tissue formation at earlier stages. Therefore, such novel strontium-incorporated borosilicate may act as a new generation of biomaterial for bone regeneration, which not only renders boron as a nutritious element for bone health, but also delivers strontium to stimulate formation of new bones.
硼在许多生命过程中发挥着重要作用，包括胚胎发生、骨骼生长和维持、免疫功能和精神运动技能。因此，通过硼酸盐玻璃的降解来输送硼在生物医学应用中具有特殊的意义。然而，随着硼的快速释放而产生的硼酸盐玻璃的细胞毒性必须仔细考虑。在这项研究中，人们发现锶的掺入不仅可以减缓硼的快速释放，还可以诱导成骨样细胞 SaOS-2 的黏附，从而显著提高硼酸盐玻璃的细胞相容性。具有多孔结构的磷灰石的多层形成表明完全降解是乐观的，并且被磷灰石覆盖的 SaOS-2 扩散形成三明治结构可能会在早期诱导类似骨骼组织的形成。因此，这种新型的锶掺杂硼硅酸盐可能成为新一代的骨再生生物材料，它不仅将硼作为一种有益于骨骼健康的营养元素，还将锶输送到体内以刺激新骨的形成。
