Balkaya Hacer, Demirbuğa Sezer, Dayan Serkan, Baktır Seda
Department of Restorative Dentistry, Erciyes University Faculty of Dentistry, 38039, Kayseri, Turkey.
Drug Application and Research Center, Erciyes University, Kayseri, Turkey.
Odontology. 2025 Apr;113(2):598-606. doi: 10.1007/s10266-024-00995-1. Epub 2024 Sep 16.
This study aimed to investigate the surface hardness, monomer conversion, surface roughness, boron release, and water sorption-solubility properties of experimental resin composites (RC) containing hydroxyapatite nanocarriers (HAP) loaded with different boron compounds, in comparison to a conventional RC. In this study, boron nitride and 4-borono-L-phenylalanine were loaded into mesoporous and nonporous HAP. 1% boron-nanocarrier complexes were added to a conventional resin-composite content. The study groups were designated based on the boron compound and nanocarrier type: Group 1 (Control): (a conventional RC), Group 2: Experimental RC containing mesoporous HAP loaded with boron nitride (BN@MHAP), Group 3: Experimental RC containing nonporous HAP loaded with boron nitride (BN@HAP), Group 4: Experimental RC containing mesoporous HAP loaded with 4-borono-L-phenylalanine (BPA@MHAP), Group 5: Experimental RC containing nonporous HAP loaded with 4-borono-L-phenylalanine (BPA@HAP). Vickers microhardness, surface roughness, degree of monomer conversion, water sorption-solubility, and boron release analyses were conducted on the RC samples. The nanoparticles were characterized using the Energy Dispersive X-ray Spectroscopy (EDX) for elemental analysis and mapping, X-ray Diffraction (XRD) for examining crystal structure, Fourier-Transform Infrared Spectroscopy (FTIR) for evaluating molecular bond structure, and Scanning Electron Microscopy (SEM) for observing surface morphology of mesoporous and non-porous HAP. No statistically significant difference was found between the experimental RC materials containing boron-nanocarrier complexes and the control group in terms of monomer conversion, surface hardness, surface roughness, water sorption and solubility (p > 0.05). However, all experimental groups demonstrated significantly higher boron release rates over time (p < 0.05), with BN@HAP and BPA@MHAP groups exhibiting the highest release rates at all timepoints (p < 0.05). The addition of 1% BN@HAP/MHAP or BPA@HAP/MHAP to the RC is promising for developing an antibacterial RC capable of releasing boron without compromising the tested physico-chemical properties of the material.
本研究旨在调查与传统树脂复合材料（RC）相比，含有负载不同硼化合物的羟基磷灰石纳米载体（HAP）的实验性树脂复合材料（RC）的表面硬度、单体转化率、表面粗糙度、硼释放以及吸水-溶解性特性。在本研究中，将氮化硼和4-硼-L-苯丙氨酸负载到介孔和无孔HAP中。将1%的硼-纳米载体复合物添加到传统树脂复合材料成分中。根据硼化合物和纳米载体类型对研究组进行命名：第1组（对照组）：（一种传统RC），第2组：含有负载氮化硼的介孔HAP的实验性RC（BN@MHAP），第3组：含有负载氮化硼的无孔HAP的实验性RC（BN@HAP），第4组：含有负载4-硼-L-苯丙氨酸的介孔HAP的实验性RC（BPA@MHAP），第5组：含有负载4-硼-L-苯丙氨酸的无孔HAP的实验性RC（BPA@HAP）。对RC样品进行维氏显微硬度、表面粗糙度、单体转化率、吸水-溶解性和硼释放分析。使用能量色散X射线光谱（EDX）进行元素分析和绘图来表征纳米颗粒，使用X射线衍射（XRD）检查晶体结构，使用傅里叶变换红外光谱（FTIR）评估分子键结构，使用扫描电子显微镜（SEM）观察介孔和无孔HAP的表面形态。在单体转化率、表面硬度、表面粗糙度、吸水和溶解性方面，含有硼-纳米载体复合物的实验性RC材料与对照组之间未发现统计学上的显著差异（p＞0.05）。然而，所有实验组随着时间的推移均表现出显著更高的硼释放率（p＜0.05），BN@HAP和BPA@MHAP组在所有时间点均表现出最高的释放率（p＜0.05）。向RC中添加1%的BN@HAP/MHAP或BPA@HAP/MHAP有望开发出一种能够释放硼且不影响材料测试的物理化学性质的抗菌RC。
