Place Elsie S, Evans Nicholas D, Stevens Molly M
Department of Materials, Imperial College London, London SW7 2AZ, UK.
Nat Mater. 2009 Jun;8(6):457-70. doi: 10.1038/nmat2441.
The molecular and physical information coded within the extracellular milieu is informing the development of a new generation of biomaterials for tissue engineering. Several powerful extracellular influences have already found their way into cell-instructive scaffolds, while others remain largely unexplored. Yet for commercial success tissue engineering products must be not only efficacious but also cost-effective, introducing a potential dichotomy between the need for sophistication and ease of production. This is spurring interest in recreating extracellular influences in simplified forms, from the reduction of biopolymers into short functional domains, to the use of basic chemistries to manipulate cell fate. In the future these exciting developments are likely to help reconcile the clinical and commercial pressures on tissue engineering.
细胞外环境中编码的分子和物理信息，为新一代用于组织工程的生物材料的开发提供了依据。几种强大的细胞外影响因素已经被应用于具有细胞指导作用的支架中，而其他一些因素在很大程度上仍未被探索。然而，对于商业成功而言，组织工程产品不仅必须有效，而且还必须具有成本效益，这就导致了在复杂性需求和生产简易性之间可能存在的矛盾。这激发了人们对以简化形式重现细胞外影响因素的兴趣，从将生物聚合物降解为短功能域，到使用基础化学方法来操纵细胞命运。未来，这些令人兴奋的发展可能有助于协调组织工程所面临的临床和商业压力。
